102878-26-2

Basic information

• Product Name: Ketone,6-ethyl-2-pyridylmethyl
• Synonyms: Ketone,6-ethyl-2-pyridylmethyl;Ketone, 6-ethyl-2-pyridyl methyl (6CI)
• CAS NO: 102878-26-2
• Molecular Formula: C₉H₁₁NO
• Molecular Weight: 268.3535
• Product Categories: PYRIDINE;ACETYLGROUP
• Mol File: 102878-26-2.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: Ketone,6-ethyl-2-pyridylmethyl(CAS DataBase Reference)
• NIST Chemistry Reference: Ketone,6-ethyl-2-pyridylmethyl(102878-26-2)
• EPA Substance Registry System: Ketone,6-ethyl-2-pyridylmethyl(102878-26-2)

Safety Data

• Hazardous Substances Data: 102878-26-2(Hazardous Substances Data)

Upstream product

• 935-28-4 2,6-diethylpyridine 

Relevant articles and documents

Organopromoted Selectivity-Switchable Synthesis of Polyketones

In this work, an organopromoted metal-free pharmaceutical-oriented selectivity-switchable benzylic oxidation was developed, affording mono-, di-, and trioxygenation products, respectively, using oxygen as the oxidant under mild conditions. This process facilitates dioxygenation of 2,6-benzylic positions of heterocycles, which could be inhibited by heterocycle chelation to the metal cocatalysts. Enantiopure chiral ketones could also be prepared. The noninvolvement of transition metals and toxins avoids metal or hazardous residues, consequently ensuring a final-stage gram-scale synthesis of Lenperone.

Method for directly oxidizing benzyl-position C-H bond into ketone

The invention discloses a method for directly oxidizing a benzyl-position C-H bond into ketone, wherein aryl ethyl compounds are catalyzed and oxidized by nitrite ester; a synergistic catalytic system of free radical initiator and nitrite ester is adopted, and a catalytic system of non-metallic catalyst and oxygen is adopted, the oxidization of the C-H bond of a free radical-activated aryl side chain is simple in operation; after completing the reaction, petroleum ether/ethyl acetate at a volume ratio of (50-1):1 is used as an eluent; column chromatography separation is performed to obtain a target product. The catalytic system in the invention uses oxygen as an oxygen source and has high atomic economy; the invention is a non-metallic catalytic system and provides a novel method for avoid metal residues in synthetic drugs; for diethyl aromatic hydrocarbon, the method provided by the invention can be adopted to selectively oxidize diethyl aromatic hydrocarbon into monoketone and diketone; the method of the invention can be adopted to efficiently synthesize tranquillizer lenperone, so that a novel method for synthesizing lenperone is provided.