- Substituted thiophene compound Preparation method and application thereof (by machine translation)
-
The invention relates to a thiophene compound represented by general formula I, a pharmaceutically acceptable salt thereof, a preparation method thereof, a pharmaceutical composition containing the thiophene compound and application thereof. The thiophene compound and a pharmaceutically acceptable salt thereof are taken as a novel estrogen-related receptor α (ERR RR) inverse agonist. These compounds can be used to treat diseases associated with ERR and ERR RR, such as cancer, osteoporosis, diabetes, anti-aging, slimming, and the like. After further optimization and screening, the drug is expected to be developed into novel drugs for preventing and treating tumors or other ERR RR related diseases. (by machine translation)
- -
-
Paragraph 0403-0405
(2021/01/11)
-
- NOVEL COMPOUNDS
-
The present invention relates to substituted 5-membered nitrogen containing heteroaryl compounds, such as sulfonyl triazoles, where the heteroaryl ring is further substituted, optionally via a linking group such as -NH-, with a cyclic group which in turn is substituted at the α-position. The present invention further relates to associated salts, solvates, prodrugs and pharmaceutical compositions, and to the use of such compounds in the treatment and prevention of medical disorders and diseases, most especially by NLRP3 inhibition.
- -
-
Page/Page column 179
(2019/11/19)
-
- ACID-CLEAVABLE MONOMER AND POLYMERS INCLUDING THE SAME
-
A monomer having formula (I): wherein in formula (I), groups and variables are the same as described in the specification.
- -
-
Paragraph 0119; 0120
(2018/10/21)
-
- EP4 RECEPTOR AGONIST, COMPOSITIONS AND METHODS THEREOF
-
This invention relates to potent selective agonists of the EP4 subtype of prostaglandin E2 receptors, their use or a formulation thereof in the treatment of glaucoma and other conditions, which are related to elevated intraocular pressure in th
- -
-
Page/Page column 26
(2008/06/13)
-
- PYRIDO[2,3-D]PYRIMIDINE-2,4-DIAMINES AS PDE 2 INHIBITORS
-
The invention provides compounds of formula (I) prodrugs thereof, and the pharmaceutically acceptable salts of the compounds or prodrugs, wherein n, X, and Y are as defined herein; pharmaceutical compositions thereof; combinations thereof; and uses thereo
- -
-
Page/Page column 26
(2010/02/12)
-
- Arocalciferols: Synthesis and biological evaluation of aromatic side-chain analogues of 1α,25-dihydroxyvitamin D31a
-
Aromatic side-chain analogues (arocalciferols 6-9) of the steroid hormone 1α,25-dihydroxyvitamin D3 (1) were synthesized and biologically evaluated. The analogues were prepared by coupling the vitamin D A-ring enyne 14 with the appropriate enol
- Figadere,Norman,Henry,Koeffler,Zhou,Okamura
-
p. 2452 - 2463
(2007/10/02)
-