10289-05-1

Basic information

• Product Name: N-[(1S)-2-Hydro×y-1-benzylethyl]Metho×y carbo×aMide
• Synonyms: N-[(1S)-2-Hydro×y-1-benzylethyl]Metho×y carbo×aMide;(S)-Methyl (1-hydroxy-3-phenylpropan-2-yl)carbamate
• CAS NO: 10289-05-1
• Molecular Formula: C₁₁H₁₅NO₃
• Molecular Weight: 209.2417
• Mol File: 10289-05-1.mol

Chemical Properties

• Appearance: /
• Storage Temp.: 2-8°C
• CAS DataBase Reference: N-[(1S)-2-Hydro×y-1-benzylethyl]Metho×y carbo×aMide(CAS DataBase Reference)
• NIST Chemistry Reference: N-[(1S)-2-Hydro×y-1-benzylethyl]Metho×y carbo×aMide(10289-05-1)
• EPA Substance Registry System: N-[(1S)-2-Hydro×y-1-benzylethyl]Metho×y carbo×aMide(10289-05-1)

Safety Data

• Hazardous Substances Data: 10289-05-1(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
N-[(1S)-2-Hydroxy-1-benzylethyl]Methoxy carbamide is utilized as a building block in the synthesis of various organic compounds and pharmaceuticals. Its unique structural features allow it to serve as a key component in the creation of novel drugs with potential therapeutic applications.
Used in Drug Development:
In the realm of drug development, N-[(1S)-2-Hydroxy-1-benzylethyl]Methoxy carbamide is employed for its potential pharmacological properties. It may contribute to the treatment of specific medical conditions by modulating biological processes at the molecular level. Further research is necessary to explore its full therapeutic potential and optimize its use in medicinal chemistry.
Used in Research and Testing:
N-[(1S)-2-Hydroxy-1-benzylethyl]Methoxy carbamide is also used in research and testing to understand its chemical and biological properties comprehensively. This knowledge is crucial for identifying its possible applications and limitations in the development of new pharmaceuticals and for ensuring the safety and efficacy of any resulting treatments.

Upstream product

• 3182-95-4 L-Phenylalaninol 
• 79-22-1 methyl chloroformate 

Downstream Products

• 154659-31-1 (S)-2-methoxycarbonylamino-3-phenylpropanal 
• 209787-89-3 ((S)-2-Phenyl-1-phenylsulfanylmethyl-ethyl)-carbamic acid methyl ester 
• 245107-67-9 N-[(1S)-2-Fluoro-1-benzylethyl]methoxy carboxamide 
• 154659-13-9 (2S,3R,4R)-2--6-methyl-1-phenylheptane-3,4-diol 

Relevant articles and documents

O-Alkyl S-(Pyridin-2-yl)carbonothiolates: Operationally Simple and Highly Nitrogen-Selective Reagents for Alkoxy Carbonylation of Amino Groups

Amino groups are selectively protected in good yields by reaction with O-Alkyl S-(pyridin-2-yl)carbonothiolates in an appropriate solvent at room temperature in air. Even glucosamine, which contains multiple hydroxyl groups, is selectively N-protected in methanol.

Chiral β-amino sulfoxides. Synthesis, configurational assignment and conformational analysis based on X-ray, CD, 1H NMR and theoretical calculations

Enantiomerically pure u and l β-amino sulfoxides have been easily obtained from the respective homochiral α-amino alcohols. The absolute configuration at the created stereogenic centre was assigned by CD spectra and by X-ray analysis. Conformational analysis of the title compounds was carried out using quantum chemical energy-geometry optimization. Thus established conformational behavior explained the strongly configuration dependent NMR spectral patterns observed for the u and l diastereomers.

Pinacol cross coupling of 2-[N-(alkoxycarbonyl)amino] aldehydes and aliphatic aldehydes by [V2Cl3(THF)6]2[Zn2Cl 6]. Synthesis of syn,syn-3-[N-(alkoxycarbonyl)amino] 1,2-diols

Slow addition of 2-[N-(alkoxycarbonyl)amino] aldehydes to mixtures of [V2Cl3(THF)6]2[Zn2Cl 6] and aliphatic aldehydes gave syn,syn-3-[N-(alkoxycarbonyl)amino] 1,2-diols in good yield and high enantiomeric purity (>99:1). The alkyl group of the N-alkoxycarbonyl was shown to influence the yield: Me > allyl > Bn > t-Bu. Only the syn,syn diastereomer was observed (>20:1), except with N-Cbz-alaninal (10:1:1), O-benzyl-N-Cbz-serinal (7:1), and N-Cbz-prolinal (5:1 to 12:1). A new serinai derivative, N-Cbz-O-TBS-serinal, was cross coupled with n-pentadecanal to give a derivative of xylo-D-C18-phytosphingosine.