- Polymerizable liquid crystal compound
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PROBLEM TO BE SOLVED: To provide a polymerizable compound giving high refractive index anisotropy, a wide liquid crystal phase temperature range and high storage stability to a liquid crystal composition and producing a polymer film having high pattern resolution, high heat resistance, and little haze and white irregularity when polymerizing the liquid crystal composition. SOLUTION: The polymerizable compound is represented by general formula (I). The polymerizable liquid crystal composition contains the polymerizable compound as a structural member. COPYRIGHT: (C)2013,JPOandINPIT
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Paragraph 0122; 0123
(2019/04/02)
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- Bromination of phenols in bromoperoxidase-catalyzed oxidations
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Phenol and ortho-substituted derivatives furnish products of selective para-bromination, if treated with sodium bromide, hydrogen peroxide, and the vanadate(V)-dependent bromoperoxidase I from the brown alga Ascophyllum nodosum. Relative rates of bromination in morpholine-4-ethane sulfonic acid (MES)-buffered aqueous tert-butanol (pH 6.2) increase by a factor 32, as the ortho-substituent in a phenol changes from F via Cl, OCH3, C(CH 3)3, and H to CH3. The polar effect in phenol bromination by the enzymatic method, according to a Hammett-correlation (ρ=-3), compares to reactivity of molecular bromine under identical conditions (ρ=-2). Hypobromous acid is not able to electrophilically substitute bromine for hydrogen at pH 6.2 in aqueous tert-butanol. The tribromide anion behaves in MES-buffered aqueous tert-butanol as electrophile (ρ~-3), showing a similar polar effect in phenol bromination as molecular bromine.
- Wischang, Diana,Hartung, Jens
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p. 9456 - 9463
(2012/11/07)
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- MODULATORS OF DOPAMINE NEUROTRANSMISSION
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The present invention relates to novel 1-(2,3-dihydro-1,4-benzodioxin-2-yl)- methanamine derivatives, useful as modulators of dopamine neurotransmission, and more specifically as dopaminergic stabilizers. In other aspects the invention relates to the use of these compounds in a method for therapy and to pharmaceutical compositions comprising the compounds of the invention.
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Page/Page column 62
(2009/12/05)
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- Applicability aspects of transition metal-catalyzed aromatic amination protocols in medicinal chemistry
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The application of palladium- and coppercatalyzed reactions for the aromatic amination of pharmacologically relevant scaffolds is investigated. The focus is set on the scope of several protocols for the introduction of amines of broad structural diversity, allowing for the synthesis of numerous derivatives of one biological hit structure for screening in biological assay systems. Thus, attaining optimized yields and TONs had not a major priority, most important were practical aspects, that is no further purification and drying of reagents and solvents had to be envisaged, ideally only a few transition metalbased protocols had to be applied for synthesizing structurally diverse compounds in sufficient amounts (several milligrams) for screening without any finetuning of conditions and catalytic systems.
- Tasler, Stefan,Mies, Jan,Lang, Martin
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p. 2286 - 2300
(2008/09/19)
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