1029364-75-7

Basic information

• Product Name: 1-Cyclopropyl-8-ethoxy-6-fluoro-7-[(4aS,7aS)-octahydro-6H-pyrrolo[3,4-b]pyridin-6-yl]-4-oxo-1,4-dihydroquinoline-3-carboxylic acid
• Synonyms: 1-Cyclopropyl-8-ethoxy-6-fluoro-7-[(4aS,7aS)-octahydro-6H-pyrrolo[3,4-b]pyridin-6-yl]-4-oxo-1,4-dihydroquinoline-3-carboxylic acid;8-Ethoxymoxifloxacin;3-Quinolinecarboxylic acid, 1-cyclopropyl-8-ethoxy-6-fluoro-1,4-dihydro-7-[(4aS,7aS)-octahydro-6H-pyrrolo[3,4-b]pyridin-6-yl]-4-oxo-;Moxifloxacin related substance C;Moxifloxacin IMpurity C (EP);Moxifloxacin EP Impurity C;Moxifloxacin EP Impurity C Hydrochloride;1-cyclopropyl-8-ethoxy-6-fluoro-7-((4aS,7aS)-octahydropyrrolo[3,4-b]pyridin-6-yl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid
• CAS NO: 1029364-75-7
• Molecular Formula: C22H26FN3O4
• Molecular Weight: 415
• Mol File: 1029364-75-7.mol

Chemical Properties

• Boiling Point: 641.8±55.0 °C(Predicted)
• Appearance: /
• Density: 1.377±0.06 g/cm3(Predicted)
• PKA: 6.44±0.50(Predicted)
• CAS DataBase Reference: 1-Cyclopropyl-8-ethoxy-6-fluoro-7-[(4aS,7aS)-octahydro-6H-pyrrolo[3,4-b]pyridin-6-yl]-4-oxo-1,4-dihydroquinoline-3-carboxylic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 1-Cyclopropyl-8-ethoxy-6-fluoro-7-[(4aS,7aS)-octahydro-6H-pyrrolo[3,4-b]pyridin-6-yl]-4-oxo-1,4-dihydroquinoline-3-carboxylic acid(1029364-75-7)
• EPA Substance Registry System: 1-Cyclopropyl-8-ethoxy-6-fluoro-7-[(4aS,7aS)-octahydro-6H-pyrrolo[3,4-b]pyridin-6-yl]-4-oxo-1,4-dihydroquinoline-3-carboxylic acid(1029364-75-7)

Safety Data

• Safety Statements: 24/25
• Hazardous Substances Data: 1029364-75-7(Hazardous Substances Data)

Usage

Uses

8-Ethoxy Moxifloxacin is a moxifloxacin impurity.

InChI:InChI=1/C22H26FN3O4/c1-2-30-21-18-14(20(27)15(22(28)29)10-26(18)13-5-6-13)8-16(23)19(21)25-9-12-4-3-7-24-17(12)11-25/h8,10,12-13,17,24H,2-7,9,11H2,1H3,(H,28,29)/t12-,17+/m0/s1

Upstream product

• 151096-09-2 moxifloxacin 
• 721970-36-1 1-cyclopropyl-7-{(S,S)-2,8-diazabicyclo[4.3.0]non-8-yl}-6-fluoro-8-hydroxy-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid 
• 143158-55-8 C₁₅H₁₃F₂NO₄ 
• 151213-40-0 (1S,6S)-2,8-diazabicyclo[4.3.0]nonane 

Relevant articles and documents

Method for synthesizing moxifloxacin and derivatives thereof

The invention provides a method for synthesizing moxifloxacin and derivatives thereof. Aminopyrrolidone derivatives are constructed to further obtain (S,S)-2,8-diazo-bicyclo[4.3.0]nonane so as to synthesize the moxifloxacin and the derivatives thereof. The method has the beneficial effects that raw materials are wide in source and low in price; chiral resolution is not needed in a preparation process; the yield and purity are relatively high; the process cost is further reduced; obvious economic value is achieved.

Moxifloxacin impurity C preparation method

The invention relates to a method for preparing Moxifloxacin impurity C. The method specifically comprises the steps of enabling a Moxifloxacin impurity E, which serves as a starting raw material, to be subjected to reaction of four steps, i.e., amino Boc protection, ethylation, esterolysis and Boc protection removal in all, and finally, carrying out recrystallization operation once, thereby obtaining the high-purity Moxifloxacin impurity C refined product. The method has the characteristics that the synthesis route is short, the operation is simple, the obtained impurity product is relatively high in purity and can be applied to reference research, and the like.