- Synthesis, cytotoxic activity and quantum chemical calculations of new 7-thioxopyrazolo[1,5-f]pyrimidin-2-one derivatives
-
The reactions of 1-amino-2-thioxo-1,2-dihydropyrimidin derivatives 1 and 2 with chloroacetyl chloride in the presence of sodium acetate led to the formation of 7-thioxopyrazolo [1,5-f]pyrimidin-2(1H,3H,7H)-one derivatives (3 and 4) in 78–80% yields. The s
- K?kbudak, Zülbiye,Saracoglu, Murat,Akko?, Senem,?imen, Zeynep,Yilmazer, M. Izzettin,Kandemirli, Fatma
-
-
Read Online
- Synthesis, characterization, and photoluminescence properties of Cu(II), Co(II), Ni(II), and Zn(II) complexes of N-aminopyrimidine-2-thione
-
This research concentrates on the preparation, characterization, and photoluminescence properties of new Co(II), Ni(II), Cu(II), and Zn(II) complexes of N-aminopyrimidine-2-thione. The ligand and metal complexes were characterized by elemental analysis an
- Oenal, Zuelbiye,Zengin, Hueseyin,Soenmez, Mehmet
-
-
Read Online
- Synthesis, characterization, and antimicrobial and catalytic activity of a new Schiff base and its metal(II) complexes
-
We presented the synthesis of a new Schiff base and its complexes properties with some transition metal ions in this study. (1-amino-2-thioxo-4-p-tolyl-1,2-dihydropyrimidin-5-yl)(p-tolyl)methanone was synthesized as the starting material, and (1-((2-hydroxynaphthalen-1-yl)methyleneamino)-2-thioxo-4-p-tolyl-1,2-dihydropyrimidin-5-yl)(p-tolyl)methanone (Hnafmmp) (1) and its Ni(II) (2), Pd(II) (3), Pt(II) (4), Cu(II) (5), Co(II) (6) complexes were prepared using above-mentioned starting material. The structures of these new compounds (ligand and its complexes) were characterized with UV–Vis, FTIR, LC–MS, 1H NMR, 13C NMR, magnetic susceptibility, conductivity measurement, X-ray powder diffraction method, and thermal analyses techniques. The 1H NMR chemical shifts of all complexes were calculated by using the gauge-invariant atomic orbital HF (3.21G) method in DMSO phases. All measured results were compared with the experimental data. The ligand and its complexes were also evaluated as antimicrobial agents against representative strains bacteria. Furthermore, we studied the catalytic activity of these compounds in Suzuki–Miyaura cross-coupling reaction in aqueous media.
- Aslan, Halime Güzin,Akko?, Senem,K?kbudak, Zülbiye,Ayd?n, Lütfiye
-
-
Read Online
- Design, synthesis, in vitro antiproliferative activity properties, quantum chemical and molecular docking studies of novel Schiff bases incorporating pyrimidine nucleus
-
In this study, a series of new Schiff bases, based on a pyrimidine core, were synthesized by the condensation reactions of 1-amino-5-(4-methylbenzoyl)-4-p-tolylpyrimidin-2(1H)-one (1a) and 1-amino-5-(4-methylbenzoyl)-4-p-tolylpyrimidine-2(1H)-thione (1b) with different aromatic aldehyde derivatives using p-toluene sulfonic acid as a catalyst at refluxing in ethyl alcohol. The structures of these newly synthesized Schiff bases (2-11) were verified by 1H NMR, 13C NMR, IR, LC-MS (only for 2, 3, 5, 6, 8, 9, 11), and elemental analysis. The presence of characteristic peaks proving the formation of imine supports the molecules' structures. The cytotoxic effects of molecules 2-11 on the viability of breast (MDA-MB-231) and colon (DLD-1) cancer cells were investigated using the MTT method. The molecules (2-11) demonstrated in vitro antiproliferative activity in the MDA-MB-231 cell line with IC50 values ranging from 58.59 μM to ?200 μM. A compound 3 was particularly found to be the most potent anticancer drug candidate in this series with an IC50 value of 58.59 μM in MDA-MB-231. Unfortunately, neither the activity of this compound nor the others are high enough to be compared with the positive control drug cisplatin against MDA-MB-231 and DLD-1. In addition, Density Functional Theory (DFT) calculations of compounds 3, 4 and 8 were performed and the molecular docking studies of these compounds with breast cancer protein, PDB ID: 1JNX were presented to compare with experimental and theoretical results.
- Akko?, Senem,Aslan, Halime Güzin,Devim, Mahmut,K?kbudak, Zülbiye,Zeyrek, Celal Tu?rul
-
-
- Reactions of 4-(4-methylbenzoyl)-5-(4-methylphenyl)-2,3-furandione with semi/thiosemi-carbazones
-
The 4-(4-methylbenzoyl)-5-(4-methylphenyl)-2,3-furandione (1) and various semi-/thiosemicarbazones 2a-h combine with loss of carbondioxide and water yielding 1-methylenaminopyrimidine-2-one and -thione derivatives 3a-h, in moderate yields (43-59%). Hydrol
- Oenal, Zuelbiye,Yildirim, Ismail
-
p. 113 - 120
(2008/02/12)
-