- 1,4-Disubstituted-5-hydroxy-3-methylpyrazoles and some derived ring systems as cytotoxic and DNA binding agents. Synthesis, in vitro biological evaluation and in silico ADME study
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Some novel polysubstituted pyrazoles, bipyrazoles and pyranopyrazoles, supported with various chemotherapeutically-active pharmacophores, were synthesized and biologically evaluated for their cytotoxic potential. Fifteen compounds (7–9, 12, 16, 17, 19, 21
- Hany Badr, Mona,Abd El Razik, Heba Attia
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p. 442 - 457
(2017/09/27)
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- N-substituted [phenyl-pyrazolo]-oxazin-2-thiones as COX-LOX inhibitors: Influence of the replacement of the oxo -group with thioxo- group on the COX inhibition activity of N-substituted pyrazolo-oxazin-2-ones
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Targeting to the synthesis of potent dual acting COX/LOX inhibitors as future anti-inflammatory drugs, we attempted a modification of the compounds based on docking analysis results. A substitution of the oxygen of the oxo-group of the oxazin-2-one ring b
- Bennamane, Nora,Nedjar-Kolli, Bellara,Geronikaki, Athina A.,Eleftheriou, Phaedra Th.,Kaoua, Rachedine,Boubekeur, Kamal,Hoffman, Pascal,Chaudhary, Shailendra S.,Saxenaf, Anil K.
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