102997-29-5

Basic information

• Product Name: 5-AMINO-1-ETHYL-3-METHYL-1H-PYRAZOLE-4-CARBONITRILE
• Synonyms: 5-AMINO-1-ETHYL-3-METHYL-1H-PYRAZOLE-4-CARBONITRILE;1H-Pyrazole-4-carbonitrile,5-amino-1-ethyl-3-methyl-(9CI)
• CAS NO: 102997-29-5
• Molecular Formula: C₇H₁₀N₄
• Molecular Weight: 150.18
• Product Categories: AMINEPRIMARY
• Mol File: 102997-29-5.mol

Chemical Properties

• Appearance: /
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 5-AMINO-1-ETHYL-3-METHYL-1H-PYRAZOLE-4-CARBONITRILE(CAS DataBase Reference)
• NIST Chemistry Reference: 5-AMINO-1-ETHYL-3-METHYL-1H-PYRAZOLE-4-CARBONITRILE(102997-29-5)
• EPA Substance Registry System: 5-AMINO-1-ETHYL-3-METHYL-1H-PYRAZOLE-4-CARBONITRILE(102997-29-5)

Safety Data

• Hazardous Substances Data: 102997-29-5(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Synthesis:
5-AMINO-1-ETHYL-3-METHYL-1H-PYRAZOLE-4-CARBONITRILE is used as a key intermediate in the synthesis of pharmaceuticals for its ability to be incorporated into the molecular structures of various drugs. Its presence in these compounds can influence their pharmacological properties, such as potency, selectivity, and bioavailability.
Used in Agrochemical Production:
In the agrochemical industry, 5-AMINO-1-ETHYL-3-METHYL-1H-PYRAZOLE-4-CARBONITRILE serves as an intermediate in the production of pesticides and other agrochemicals. Its unique chemical structure allows it to be a component of compounds that can target specific pests or enhance crop protection.
Used in Organic Compounds Synthesis:
5-AMINO-1-ETHYL-3-METHYL-1H-PYRAZOLE-4-CARBONITRILE is utilized as a building block in the synthesis of a range of organic compounds. Its functional groups enable it to participate in various chemical reactions, facilitating the creation of new molecules with specific properties for different applications.
Used in Medicinal Chemistry Research:
Due to its potential biological and pharmacological activities, 5-AMINO-1-ETHYL-3-METHYL-1H-PYRAZOLE-4-CARBONITRILE is a subject of interest for research and development in medicinal chemistry. Scientists explore its interactions with biological targets to discover new therapeutic agents or to improve existing ones.
Used in Chemical Intermediates for Various Industries:
5-AMINO-1-ETHYL-3-METHYL-1H-PYRAZOLE-4-CARBONITRILE is employed as a chemical intermediate across multiple industries, including but not limited to the chemical, material science, and pharmaceutical sectors. Its role as an intermediate allows for the production of a wide array of end products with diverse applications.

Upstream product

• 624-80-6 ethylhydrazine 
• 89943-20-4 2-cyano-3-ethoxythiocrotonamide 
• 6629-60-3 ethylhydrazine oxalic acid salt 
• 5417-82-3 (1-ethoxyethylidene)malononitrile 

Downstream Products

• 1028303-96-9 N-(4-Cyano-2-ethyl-5-methyl-2H-pyrazol-3-yl)-5-nitro-2-propoxy-benzamide 
• 175406-88-9 1-Ethyl-3-methyl-6-(2-propoxy-phenyl)-1,5-dihydro-pyrazolo[3,4-d]pyrimidin-4-one 
• 168465-01-8 1-ethyl-3-methyl-6-(5-bromo-2-propoxyphenyl)-1,5-dihydro-pyrazolo[3,4-d]pyrimidin-4-one 
• 168464-31-1 1-Ethyl-3-methyl-6-(2-propoxy-5-aminophenyl)-1,5-dihydro-pyrazolo[3,4-d]pyrimidin-4-one 
• 168464-58-2 1-Ethyl-3-methyl-6-(5-cyano-2-propoxyphenyl)-1,5-dihydro-pyrazolo[3,4-d]pyrimidin-4-one 
• 175406-91-4 6-(5-Acetyl-2-propoxy-phenyl)-1-ethyl-3-methyl-1,5-dihydro-pyrazolo[3,4-d]pyrimidin-4-one 
• 168464-59-3 1-Ethyl-3-methyl-6-(2-propoxy-5-thiocarbamoylphenyl)-1,5-dihydro-pyrazolo[3,4-d]pyrimidin-4-one 
• 168465-03-0 3-(1-Ethyl-3-methyl-4-oxo-4,5-dihydro-1H-pyrazolo[3,4-d]pyrimidin-6-yl)-4-propoxy-benzoic acid methyl ester 
• 168464-25-3 1-Ethyl-3-methyl-6-(2-propoxy 5-nitrophenyl)-1,5-dihydro-pyrazolo [3,4-d]pyrimidin-4-one 
• 168465-04-1 1-ethyl-3-methyl-6-(2-propoxy-5-bromoacetylphenyl)-1,5-dihydropyrazolo[3,4-d]pyrimidin-4-one 
• 168464-71-9 3-(1-Ethyl-3-methyl-4-oxo-4,5-dihydro-1H-pyrazolo[3,4-d]pyrimidin-6-yl)-4-propoxy-benzoic acid hydrazide 

Relevant articles and documents

SULFONYLUREIDOPYRAZOLE DERIVATIVES

A sulfonylureidopyrazole derivative of formula (1) or (2) is disclosed. The derivative has an inhibitory activity on endothelin converting enzyme, and is useful for treating or preventing various cardiac failures, tracheal constrictions, nervous disorders, parasecretion, vascular disorders, various ulcers and the like.

Synthesis and cyclic GMP phosphodiesterase inhibitory activity of a series of 6-phenylpyrazolo[3,4-d]pyrimidones

A series of 6-phenylpyrazolo[3,4-d]pyrimidones is described which are specific inhibitors of cGMP specific (type V) phosphodiesterase. Enzymatic and cellular activity as well as in vivo oral antihypertensive activity are evaluated. A n-propoxy group at the 2-position of the phenyl ring is necessary for activity. A series of products substituted at the 5-position in addition to the 2-n-propoxy was prepared and evaluated. This position can accommodate many unrelated groups. Amino derivatives were very potent but lacked metabolic stability. Substitution by carbon-linked small heterocycles provided both high levels of activity and stability. Cellular activity very often correlated with in vivo activity. Among the compounds, 1,3-dimethyl-6- (2-propoxy-5-methanesulfonamidophenyl)-1,5-dihydropyrazolo[3,4-d]pyrimidin- 4-one (38) and 1-ethyl-3-methyl-6-(2-propoxy-5-(4-methylthiazol-2-yl)phenyl)- 1,5-dihydropyrazolo[3,4-d]pyrimidin-4-one (59) displayed outstanding in vivo activities at 5 mg/kg/os and good metabolic stabilities.