cas 10300-27-3, 2-amino-9-[(2R,3R,4S,5R)-3-hydroxy-5-(hydroxymethyl)-4-methoxyoxolan-2-yl]-3H-purin-6-one

Articles about 10300-27-3Total 3 be found

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Synthesis of 9-(3-Deoxy-3-fluoro-&β-D-ribofuranosyl)guanine, a New Potent Antiviral Agent
The title compound (5) was prepared by reacting a corresponding nucleoside of xylo configuration with (diethylamino)sulphur trifluoride (DAST).
Puech, Frederic,Gosselin, Gilles,Imbach, Jean-Louis
p. 955 - 957
(2007/10/02)

Methylation of Nucleosides with Trimethylsulfonium Hydroxide. Effects of Transition Metal Ions
The effect of transition metal acetylacetonates on the methylation of ribo- and deoxyribonucleosides with trimethylsulfonium hydroxide was studied.With ribonucleosides the metal complexes promoted O'-methylation at the 2' and 3' positions of the ribosyl group.A comparable effect was not observed in methylation of deoxyribonucleosides.These results are attributed to an increase in the nucleophilicity of the 2'-OH and 3'-OH groups of the ribosides through complex formation with the metal ion; such a complex cannot form with the deoxyribose derivatives.The activity of the metal ions studied for promoting this O'-methylation increased in the order Mn2+ 2+ = Zn2+ 2+ 2+ 3+.These M(AA)n also suppressed N-methylation of the purine and pyrimidine rings of adenosine and cytidine.It is suggested that this result may be caused by coordination of the metal ions with ring nitrogens.
Yamauchi, Kiyoshi,Nakagima, Toru,Kinoshita, Masayoshi
p. 3865 - 3868
(2007/10/02)

Methylation study of ribonucleosides, deoxyribonucleosides, and 2′-O-methylribonucleosides with trimethylsulphonium hydroxide and trimethylsulphonium iodide. Influence of the 2′-hydroxy-groups on the reactivity of the base moieties of ribonucleosides
Methylations of the naturally occuring ribonucleoside (1), deoxyribonucleoside (2), and 2′-O-methylribonucleoside (3) were carried out using trimethylsulphonium hydroxide (Me3SOH) and trimethylsulphonium iodide (Me3Sl). The base moiety of (2) and (3) are more reactive than the corresponding base moiety of (1). The sites and extent of methylation of (2) are considerably different from those of (1), but are almost identical with those of (3). The reactivities of (1)-(3) are discussed in connection to an intramolecular interaction of the 2′-OH groups with the base moiety of (1). The methylating characteristics of Me 3SOH and Me3Sl are also described. The kinetics indicate an SN2 mechanism for methylation of nucleosides by Me 3S+ ions.
Yamauchi, Kiyoshi,Nakagima, Toru,Kinoshita, Masayoshi
p. 2787 - 2792
(2007/10/02)

Chemical Properties

Melting Point: 263-300 °C (decomp)
Boiling Point: 711.7°Cat760mmHg
Flash Point:384.2°C
Density: 1.98g/cm³
PKA: 9?+-.0.20(Predicted)
PSA: 148.51000
LogP: -1.45140

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10300-27-3

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Chemical Properties

Melting Point: 263-300 °C (decomp)

Boiling Point: 711.7°Cat760mmHg

Flash Point:384.2°C

Density: 1.98g/cm³

PKA: 9?+-.0.20(Predicted)

PSA: 148.51000

LogP: -1.45140

Global suppliers and manufacturers of 10300-27-3total 29 suppliers on LookChem

Article Database

10300-27-3

Articles about 10300-27-3Total 3 be found

More Articles about upstream products of 10300-27-3

Chemical Properties

Melting Point: 263-300 °C (decomp)

Boiling Point: 711.7°Cat760mmHg

Flash Point:384.2°C

Density: 1.98g/cm3

PKA: 9?+-.0.20(Predicted)

PSA: 148.51000

LogP: -1.45140

Global suppliers and manufacturers of 10300-27-3total 29 suppliers on LookChem

Density: 1.98g/cm³