- Phenylenediamine urotensin-II receptor antagonists and CCR-9 antagonists
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The present invention relates to urotensin II receptor antagonists, CCR-9 antagonists, pharmaceutical compositions containing them and their use.
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- Process for the preparation of aromatic or heteroaromatic sulphonyl chlorides
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Aromatic or heteroaromatic sulphonyl chlorides of the general formula I in which X may be a C or N, R1may be fluorine, chlorine, bromine, nitro, methoxy, fluoromethoxy, difluoromethoxy, trifluoromethoxy, C1-C4alkyl or phenyl, R2may be H, fluorine, chlorine, bromine, OH, C1-C4alkyl, are prepared by diazotization of the compounds of the general formula II in which X, R1and R2are as defined for formula (I), and decomposition of the resulting diazonium salts in the presence of sulphur dioxide and a copper catalyst, where the compounds of the formula (II) are treated, in a mixture with one or more organic solvents, sulphur dioxide and a copper catalyst, with hydrogen chloride and alkyl nitrite at temperatures of from ?20 to +60° C.
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(2008/06/13)
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