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1-BOC-3-(TOLUENE-4-SULFONYLOXY)-PYRROLIDINE is a chemical with a specific purpose. Lookchem provides you with multiple data and supplier information of this chemical.

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  • 103057-45-0 Structure
  • Basic information

    1. Product Name: 1-BOC-3-(TOLUENE-4-SULFONYLOXY)-PYRROLIDINE
    2. Synonyms: 1-BOC-3-(TOLUENE-4-SULFONYLOXY)-PYRROLIDINE;1-Boc-3-tosyloxypyrrolidine;tert-Butyl 3-{[(4-methylphenyl)sulfonyl]-oxy}pyrrolidine-1-carboxylate;3-[[(4-Methylphenyl)sulfonyl]oxy]-1-Pyrrolidinecarboxylic Acid 1,1-DiMethylethyl Ester;tert-Butyl 3-[[(4-Methylphenyl)sulfonyl]oxy]-1-pyrrolidinecarboxylate;tert-butyl 3-{[(4-methyl-1l4-thiopyran-1-yl)sulfonyl]oxy}pyrrolidine-1-carboxylate;1-BOC-3-(TOLUENE-4-SULFONYLOXY)-PYRROLIDIN;tert-butyl 3-(tosyloxy)pyrrolidine-1-carboxylate
    3. CAS NO:103057-45-0
    4. Molecular Formula: C16H23NO5S
    5. Molecular Weight: 341.42
    6. EINECS: N/A
    7. Product Categories: Aromatics;Heterocycles;Sulfur & Selenium Compounds
    8. Mol File: 103057-45-0.mol
  • Chemical Properties

    1. Melting Point: 77-79?C
    2. Boiling Point: 461.916°C at 760 mmHg
    3. Flash Point: 233.159°C
    4. Appearance: /
    5. Density: 1.259g/cm3
    6. Vapor Pressure: 0mmHg at 25°C
    7. Refractive Index: 1.557
    8. Storage Temp.: Refrigerator
    9. Solubility: Chloroform, Methanol
    10. PKA: -3.58±0.40(Predicted)
    11. CAS DataBase Reference: 1-BOC-3-(TOLUENE-4-SULFONYLOXY)-PYRROLIDINE(CAS DataBase Reference)
    12. NIST Chemistry Reference: 1-BOC-3-(TOLUENE-4-SULFONYLOXY)-PYRROLIDINE(103057-45-0)
    13. EPA Substance Registry System: 1-BOC-3-(TOLUENE-4-SULFONYLOXY)-PYRROLIDINE(103057-45-0)
  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: IRRITANT
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 103057-45-0(Hazardous Substances Data)

103057-45-0 Usage

Chemical Properties

Pale Yellow Solid

Check Digit Verification of cas no

The CAS Registry Mumber 103057-45-0 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,0,3,0,5 and 7 respectively; the second part has 2 digits, 4 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 103057-45:
(8*1)+(7*0)+(6*3)+(5*0)+(4*5)+(3*7)+(2*4)+(1*5)=80
80 % 10 = 0
So 103057-45-0 is a valid CAS Registry Number.
InChI:InChI=1/C16H23NO5S/c1-12-5-7-14(8-6-12)23(19,20)22-13-9-10-17(11-13)15(18)21-16(2,3)4/h5-8,13H,9-11H2,1-4H3

103057-45-0SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 10, 2017

Revision Date: Aug 10, 2017

1.Identification

1.1 GHS Product identifier

Product name tert-butyl 3-(4-methylphenyl)sulfonyloxypyrrolidine-1-carboxylate

1.2 Other means of identification

Product number -
Other names 3-(Toluene-4-sulfonyloxy)-pyrrolidine-1-carboxylic acid tert-butyl ester

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:103057-45-0 SDS

103057-45-0Relevant articles and documents

Copper-Catalyzed Cross-Coupling between Alkyl (Pseudo)halides and Bicyclopentyl Grignard Reagents

Andersen, Claire,Bernardelli, Patrick,Cossy, Janine,Daumas, Marc,Ferey, Vincent,Guérinot, Amandine

, (2020)

The development of a copper-catalyzed cross-coupling between primary and secondary (pseudo)halides and bicyclopentyl Grignard reagents is reported. Highly strained bicyclopentanes can be cross-coupled with a large panel of primary alkyl mesylates and secondary alkyl iodides. The catalytic system is simple and cheap, and the reaction is general and chemoselective.

Discovery of Bispecific Antagonists of Retinol Binding Protein 4 That Stabilize Transthyretin Tetramers: Scaffolding Hopping, Optimization, and Preclinical Pharmacological Evaluation as a Potential Therapy for Two Common Age-Related Comorbidities

Cioffi, Christopher L.,Muthuraman, Parthasarathy,Raja, Arun,Varadi, Andras,Racz, Boglarka,Petrukhin, Konstantin

, p. 11054 - 11084 (2020/11/09)

Accumulation of cytotoxic lipofuscin bisretinoids may contribute to atrophic age-related macular degeneration (AMD) pathogenesis. Retinal bisretinoid synthesis depends on the influx of serum all-trans-retinol (1) delivered via a tertiary retinol binding protein 4 (RBP4)-transthyretin (TTR)-retinol complex. We previously identified selective RBP4 antagonists that dissociate circulating RBP4-TTR-retinol complexes, reduce serum RBP4 levels, and inhibit bisretinoid synthesis in models of enhanced retinal lipofuscinogenesis. However, the release of TTR by selective RBP4 antagonists may be associated with TTR tetramer destabilization and, potentially, TTR amyloid formation. We describe herein the identification of bispecific RBP4 antagonist-TTR tetramer kinetic stabilizers. Standout analogue (±)-44 possesses suitable potency for both targets, significantly lowers mouse plasma RBP4 levels, and prevents TTR aggregation in a gel-based assay. This new class of bispecific compounds may be especially important as a therapy for dry AMD patients who have another common age-related comorbidity, senile systemic amyloidosis, a nongenetic disease associated with wild-type TTR misfolding.

SUBSTITUTED 5-CYANOINDOLE COMPOUNDS AND USES THEREOF

-

Paragraph 00274; 00327, (2019/01/10)

A compound of Formula (I), or a pharmaceutically acceptable salt thereof, is provided that has been shown to be useful for the treatment of lysine (K)-specific demethylase 1A (LSD1) - mediated diseases or disorders, Formula (I), wherein R1, R2, R3, R4, and R5 are as defined herein.

2-AMINO-BENZIMIDAZOLE DERIVATIVES AND THEIR USE AS 5-LIPOXYGENASE AND/OR PROSTAGLANDIN E SYNTHASE INHIBITORS

-

Page/Page column 49; 50, (2016/03/12)

The present invention relates to benzimidazole derivatives having the general formula I, wherein n is 0 or 1; X1 and X2 are independently, at each occurrence, CR5 or N; Y is C1-C6 alkylene, wherein alkylene is optionally substituted with one to two C1-C3 alkyl groups; R1 is selected from the group consisting of hydrogen, halogen, C1-C6 alkoxy, -NH2, -NHR6, -NR7R8 and -NH-(R9)n-R10, n being 0 or 1; R2 is selected from the group consisting of hydrogen, halogen, C1-C6 alkyl, -NH2, -NHR6, - NR7R8 and -NH-(R9)n-R10; R3 is selected from the group consisting of hydrogen, hydroxyl, OR11, -NR7R8, C1-C6 alkoxy, C1-C6 alkyl, C3-C10 cycloalkyl, C1-C3 haloalkyl, -C(O)NHR11, aryl, heteroaryl and heterocyclyl, wherein each of said cycloalkyl, aryl, heteroaryl and heterocyclyl is optionally and independently substituted with one to four Ra groups; and R4 is selected from the group consisting of -NH2, -N(R12)(V)pR13, - NH(V)p-OR14, -NHC(O)R15, and groups of formula la shown below, and their use in the treatment of diseases, in particular inflammatory diseases, cancer, stroke and/or Alzheimer's disease.

Pyrimidine compounds and methods of making and using same

-

Page/Page column 57, (2013/02/27)

Disclosed herein are pyrimidinyl compounds that are contemplated to be modulators of cystic fibrosis transmembrane regulators (CFTR), and methods of making and using same. Also provided are pharmaceutical compositions and methods of treating disorders associated with cystic fibrosis transmembrane regulators, such as airway inflammation, cystic fibrosis, and the like.

HETEROCYCLIC COMPOUND

-

Page/Page column 63-64, (2010/07/08)

The present invention relates to wherein each symbol is as defined in the specification. The compound of the present invention has a superior RBP4-lowering action, and is useful as a medicament for the prophylaxis or treatment of disease and condition mediated by increased RBP4.

Pyrrolopyrimidines as therapeutic agents

-

, (2008/06/13)

Chemical compounds having structural formula I and physiologically acceptable salts and metabolites thereof, are inhibitors of serine/threonine and tyrosine kinase activity. Several of the kinases, whose activity is inhibited by these chemical compounds, are involved in immunologic, hyperproliferative, or angiogenic processes. Thus, these chemical compounds can ameliorate disease states where angiogenesis or endothelial cell hyperproliferation is a factor. These compounds can be used to treat cancer and hyper proliferative disorders, rheumatiod arthritis, disorders of the immune system, trasplant refections and imflammatory disorders.

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