Solid-phase total synthesis of daptomycin and analogs
An entirely solid-phase synthesis of daptomycin, a cyclic lipodepsipeptide antibiotic currently in clinical use, was achieved using a combination of ?±-azido and Fmoc amino acids. This methodology was applied to the synthesis of several daptomycin analogs, one of which did not contain kynurenine or the synthetically challenging amino acid (2S,3R)-methylglutamate yet exhibited an MIC approaching that of daptomycin.
Lohani, Chuda Raj,Taylor, Robert,Palmer, Michael,Taylor, Scott D.
Read Online
