103195-35-3

Basic information

• Product Name: ethyl 8-aMino-4-oxo-4H-chroMene-2-carboxylate
• Synonyms: ethyl 8-aMino-4-oxo-4H-chroMene-2-carboxylate;8-Amino-4-oxo-4H-1-benzopyran-2-carboxylic acid ethyl ester;ethyl 8-amino-4-oxo-4H-chromene-2-carboxylate(WXG00429)
• CAS NO: 103195-35-3
• Molecular Formula: C₁₂H₁₁NO₄
• Molecular Weight: 233.22004
• Mol File: 103195-35-3.mol

Chemical Properties

• Appearance: /
• Density: 1.359
• CAS DataBase Reference: ethyl 8-aMino-4-oxo-4H-chroMene-2-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: ethyl 8-aMino-4-oxo-4H-chroMene-2-carboxylate(103195-35-3)
• EPA Substance Registry System: ethyl 8-aMino-4-oxo-4H-chroMene-2-carboxylate(103195-35-3)

Safety Data

• Hazardous Substances Data: 103195-35-3(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
Ethyl 8-amino-4-oxo-4H-chromene-2-carboxylate serves as a key intermediate in the synthesis of various drugs. Its unique structure and pharmacological properties make it a valuable compound for the development of new medications.
Used in Medical Research:
Due to its anti-inflammatory, antioxidant, and anticancer activities, ethyl 8-amino-4-oxo-4H-chromene-2-carboxylate is used as a subject of study in medical research. Scientists explore its potential applications in treating various diseases and conditions, as well as its mechanisms of action.
Used in Agriculture:
Ethyl 8-amino-4-oxo-4H-chromene-2-carboxylate may have potential applications in agriculture, possibly as a component in the development of new pesticides or as a means to enhance crop yields and resistance to diseases.
Used in Industrial Chemistry:
ethyl 8-aMino-4-oxo-4H-chroMene-2-carboxylate could be utilized in industrial chemistry for various purposes, such as the synthesis of specialty chemicals, dyes, or other products that require its unique structural and functional attributes.
Used in Material Science:
Ethyl 8-amino-4-oxo-4H-chromene-2-carboxylate may also find applications in material science, where its properties could be harnessed to develop new materials with specific characteristics, such as improved stability, reactivity, or other desirable traits.

Upstream product

• 110683-75-5 ethyl 8-nitro-4-oxo-4H-benzopyran-2-carboxylate 
• 161369-33-1 8-nitro-2-methoxycarbonyl-4-oxo-4H-1-benzopyran 
• 182356-63-4 (Z)-2-Hydroxy-4-(2-hydroxy-3-nitro-phenyl)-4-oxo-but-2-enoic acid ethyl ester 
• 28177-69-7 2-hydroxy-3-nitroacetophenone 

Downstream Products

• 1026054-90-9 C₁₈H₂₂N₂O₆S 
• 1443367-04-1 8-(4-methoxybenzamido)-4-oxo-4H-chromene-2-carboxylic acid 
• 136450-08-3 ethyl 4-oxo-8-(4-(4-phenylbutoxy)benzamido)chromene-2-carboxylate 
• 1443367-31-4 4-oxo-8-(4-propoxybenzamido)-4H-chromene-2-carboxylic acid 
• 1443367-27-8 ethyl 4-oxo-8-(4-propoxybenzamido)-4H-chromene-2-carboxylate 
• 1443367-30-3 8-(4-(cyclopropylmethoxy)benzamido)-4-oxo-4H-chromene-2-carboxylic acid 
• 1443366-70-8 ethyl 8-(4-bromobenzamido)-4-oxo-4H-chromene-2-carboxylate 
• 1443366-69-5 ethyl 8-(4-Methoxybenzamido)-4-oxo-4H-chromene-2-carboxylate 
• 1443366-68-4 ethyl 4-oxo-8-(4-(trifluoromethyl)benzamido)-4H-chromene-2-carboxylate 
• 1443366-67-3 ethyl 8-(4-methylbenzamido)-4-oxo-4H-chromene-2-carboxylate 
• 1443366-66-2 ethyl 8-(3-nitrobenzamido)-4-oxo-4H-chromene-2-carboxylate 
• 1443366-65-1 ethyl 8-(3-methylbenzamido)-4-oxo-4H-chromene-2-carboxylate 
• 1258763-55-1 ethyl 8-benzamido-4-oxo-4H-chromene-2-carboxylate 
• 1443366-59-3 ethyl 4-oxo-8-(2-phenylacetamido)-4H-chromene-2-carboxylate 

Relevant articles and documents

Malonic acid receptors with decarboxylative activity

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Development and application of a high-throughput screening assay for identification of small molecule inhibitors of the P. falciparum reticulocyte binding-like homologue 5 protein

The P. falciparum parasite, responsible for the disease in humans known as malaria, must invade erythrocytes to provide an environment for self-replication and survival. For invasion to occur, the parasite must engage several ligands on the host erythrocyte surface to enable adhesion, tight junction formation and entry. Critical interactions include binding of erythrocyte binding-like ligands and reticulocyte binding-like homologues (Rhs) to the surface of the host erythrocyte. The reticulocyte binding-like homologue 5 (Rh5) is the only member of this family that is essential for invasion and it binds to the basigin host receptor. The essential nature of Rh5 makes it an important vaccine target, however to date, Rh5 has not been targeted by small molecule intervention. Here, we describe the development of a high-throughput screening assay to identify small molecules which interfere with the Rh5-basigin interaction. To validate the utility of this assay we screened a known drug library and the Medicines for Malaria Box and demonstrated the reproducibility and robustness of the assay for high-throughput screening purposes. The screen of the known drug library identified the known leukotriene antagonist, pranlukast. We used pranlukast as a model inhibitor in a post screening evaluation cascade. We procured and synthesised analogues of pranlukast to assist in the hit confirmation process and show which structural moieties of pranlukast attenuate the Rh5 – basigin interaction. Evaluation of pranlukast analogues against P. falciparum in a viability assay and a schizont rupture assay show the parasite activity was not consistent with the biochemical inhibition of Rh5, questioning the developability of pranlukast as an antimalarial. The high-throughput assay developed from this work has the capacity to screen large collections of small molecules to discover inhibitors of P. falciparum Rh5 for future development of invasion inhibitory antimalarials.

Selective Optimization of Pranlukast to Farnesoid X Receptor Modulators

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8-Amido-chromen-4-one-2-carboxylic acid derivatives were identified as novel agonists at the G protein-coupled orphan receptor GPR35. They were characterized by a β-arrestin recruitment assay and optimized to obtain agonists with nanomolar potency for the

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