103197-11-1Relevant articles and documents
TOPICAL TREATMENT OF CATARACTS IN DOGS
-
Page/Page column 11, (2010/06/20)
The topical treatment of cataracts in dogs is a composition having an aldose reductase inhibitor (ARI) in a topical carrier. The ARI is preferably 2R,4S-6-fluoro-2-methyl-spiro[chroman-4,4'-imidazolidine]-2',5'-dione, referred to as 2R-methyl sorbinil. Th
Spectral assignments for the aldose reductase inhibitor 4(S)-2,3-dihydro-6-fluoro-2(R)-methylspiro[chroman-4,4′-imidazoline] -2′,5′-dione and its synthetic intermediates
Wang, Mingan,Mishra, Manoj K.,Zhu, Wenjun,Kador, Peter F.
, p. 1008 - 1011 (2007/10/03)
The 1H and 13C NMR chemical shifts of the aldose reductase inhibitor 4(S)-2,3-dihydro-6-fluoro-2(R)-methylspiro[chroman-4, 4′-imidazoline]-2′,5′-dione, methylsorbinil, and its seven synthetic intermediates, have been completely assigned on the basis of DEPT, COSY, g-HSQC and g-HMBC. All C-F coupling constants from one-bond to four-bond in the 13C NMR spectra and H-F and H-H coupling constants from three-bond to four-bond in 1H spectra were obtained. Copyright