Zinc-mediated addition of bromoacetonitrile to carbonyl compounds under solvent-free conditions
Zinc mediated addition reaction of bromoacetonitrile with aryl aldehydes and ketones produces β-hydroxynitriles under solvent-free conditions. The valuable feature of the methodology are solvent-free and catalyst-free conditions and short reaction times (5 min).
Catalytic nucleophilic activation of acetonitrile via a cooperative catalysis of cationic Ru complex, DBU, and NaPF6
The development of an efficient catalytic system for the direct addition of acetonitrile under mild amine basic conditions is described. A cooperative catalysis of CpRu complex, DBU, and NaPF6 enables chemoselective and catalytic generation of
Unexpected stereorecognition in nitrilase-catalyzed hydrolysis of β-hydroxy nitriles
Biocatalytic enantioselective hydrolysis of β-hydroxy nitriles to corresponding (S)-enriched β-hydroxy carboxylic acids has been achieved for the first time by an isolated nitrilase bII6402 from Bradyrhizobium japonicum USDA110. This offers a new "green" approach to optically pure β-hydroxy nitriles and β-hydroxy carboxylic acids. The observed remote stereorecognition is surprising because this nitrilase shows no enantioselectivity for the hydrolysis of α-hydroxy nitriles such as mandelonitrile.
Kamila, Sukanta,Zhu, Dunming,Biehl, Edward R.,Hua, Ling
p. 4429 - 4431
(2007/10/03)
Cooperative catalysis of a cationic ruthenium complex, amine base, and Na salt: Catalytic activation of acetonitrile as a nucleophile
Cooperative catalysis of a cationic Ru complex, DBU, and NaPF6 is described. An exquisite combination of the catalytic triad enabled catalytic activation of acetonitrile as a nucleophile under mild amine-basic conditions. Addition of in situ-ge