Synthesis of novel nitro-substituted triaryl pyrazole derivatives as potential estrogen receptor ligands
Novel tetrasubstituted pyrazole derivatives bearing a nitro substituent on their A-phenol ring were synthesized and their binding affinity towards the estrogen receptor (ER) subtypes ERα and ERβ was determined. Among compounds tested, the 2-nitrophenol derivative 5c was found to bind satisfactorily to both estrogen receptor subtypes (RBAα=5.17 and RBAβ=3.27). In general, the introduction of a nitro group into the A ring of these compounds was found to benefit their ERβ binding abilities.
Naoum, Fotini,Kasiotis, Konstantinos M.,Magiatis, Prokopios,Haroutounian, Serkos A.
p. 1259 - 1273
(2008/02/08)
More Articles about upstream products of 1032174-32-5