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1032610-59-5

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DERIVATIVES OF 6-SUBSTITUTED TRIAZOLOPYRIDAZINES AS REV-ERB AGONISTS
The present invention provides novel 6-substituted [1,2,4]triazolo[4,3-b]pyridazines that are agonists of Rev-Erb. These compounds, and pharmaceutical compositions comprising the same, are suitable means for treating any disease wherein the activation of Rev-Erb has therapeutic effects, for instance in inflammatory and circadian rhythm-related disorders or cardiometabolic diseases.
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Page/Page column 48-49; 101

(2013/04/13)

Chemical Properties

Boiling Point: 379.6±44.0 °C(Predicted)
Density: 1.13±0.1 g/cm3(Predicted)
PKA: 8.04±0.10(Predicted)
PSA: 43.70000
LogP: 0.29020

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