103336-05-6

Basic information

• Product Name: Ditekiren
• Synonyms: Ditekiren;SASWSEQJAITMKS-JJNNLWIXSA-N
• CAS NO: 103336-05-6
• Molecular Formula: C₅₀H₇₅N₉O₈
• Molecular Weight: 930.198
• Product Categories: Aromatics, Inhibitors, Pharmaceuticals, Intermediates & Fine Chemicals
• Mol File: 103336-05-6.mol

Chemical Properties

• Boiling Point: 1156.6°Cat760mmHg
• Flash Point: 653.3°C
• Appearance: /
• Density: 1.177g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.559
• CAS DataBase Reference: Ditekiren(CAS DataBase Reference)
• NIST Chemistry Reference: Ditekiren(103336-05-6)
• EPA Substance Registry System: Ditekiren(103336-05-6)

Safety Data

• Hazardous Substances Data: 103336-05-6(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
Ditekiren is used as a renin inhibitor for the treatment of hypertension and heart failure. It works by blocking the activity of renin, an enzyme that plays a crucial role in regulating blood pressure. By inhibiting renin, Ditekiren helps to lower blood pressure and improve heart function in patients with hypertension and heart failure.

InChI:InChI=1/C50H75N9O8/c1-11-33(6)43(47(64)53-29-35-20-15-16-22-52-35)57-44(61)37(32(4)5)27-42(60)38(24-31(2)3)55-46(63)41(26-36-28-51-30-54-36)58(10)48(65)39(25-34-18-13-12-14-19-34)56-45(62)40-21-17-23-59(40)49(66)67-50(7,8)9/h12-16,18-20,22,28,30-33,37-43,60H,11,17,21,23-27,29H2,1-10H3,(H,51,54)(H,53,64)(H,55,63)(H,56,62)(H,57,61)/t33-,37-,38-,39-,40-,41-,42-,43-/m0/s1

Upstream product

• 3731-51-9 2-(Aminomethyl)pyridine 
• 103322-68-5 N-α-(tert-butyloxycarbonyl)-L-isoleucyl>-2-pyridylmethylamine 
• 35899-43-5 Boc-His(Tos)-OH 
• 103818-14-0 N-α-(tert-butyloxycarbonyl)-N^α-methyl-N^im-tosyl-L-histydyl>-5(S)-amino-4(S)-hydroxy-2(S)-isopropyl-7-methyloctanoyl>-L-isoleucyl>-2-pyridylmethylamine 
• 97920-16-6 N-L-isoleucyl-2-pyridylmethylamine 
• 103372-35-6 N^α-(tert-butyloxycarbonyl)-N^α-methyl-N^im-tosyl-L-histidine 
• 103372-32-3 N-α-<4(S)-<(tert-butyldimethylsilyl)oxy>-5(S)-<(tert-butyloxycarbonyl)amino>-2(S)-isopropyl-7-methyloctanoyl>-L-isoleucyl>-2-pyridylmethylamine 
• 13139-16-7 N-(tert-butyloxycarbonyl)-L-isoleucine 
• 160948-75-4 C₅₀H₇₃N₉O₈ 
• 103336-04-5 N-α-<(tert-butyloxycarbonyl)-L-prolyl-L-phenylalanyl>-N^α-methyl-N^im-tosyl-L-histydyl>-5(S)-amino-4(S)-hydroxy-2(S)-isopropyl-7-methyloctanoyl>-L-isoleucyl>-2-pyridylmethylamine 

Downstream Products

• 130985-52-3 N-α--L-prolyl>-L-phenylalanyl>-N^α-methyl-L-histydyl>-5(S)-amino-4(S)-hydroxy-2(S)-isopropyl-7-methyloctanoyl>-L-isoleucyl>-2-pyridylmethylamine 
• 130985-54-5 C₄₉H₇₄N₉O₁₁P 
• 130985-53-4 N-α--L-prolyl>-L-phenylalanyl>-N^α-methyl-L-histydyl>-5(S)-amino-4(S)-hydroxy-2(S)-isopropyl-7-methyloctanoyl>-L-isoleucyl>-(1-oxo-2-pyridyl)methylamine 
• 130985-55-6 C₄₉H₇₄N₉O₁₂P 
• 130985-40-9 N-α-acetyl>l-prolyl>-L-phenylalanyl>-N^α-methyl-L-histydyl>-5(S)-amino-4(S)-hydroxy-2(S)-isopropyl-7-methyloctanoyl>-L-isoleucyl>-2-pyridylmethylamine 
• 130985-41-0 N-α-acetyl>-L-prolyl>-L-phenylalanyl>-N^α-methyl-L-histydyl>-5(S)-amino-4(S)-hydroxy-2(S)-isopropyl-7-methyloctanoyl>-L-isoleucyl>-(1-oxo-2-pyridyl)methylamine 

Relevant articles and documents

Synthesis of tritium labeled renin inhibitor ditekiren

In the search for a radioactive form of the peptidomimetic renin inhibitor, ditekiren, with a metabolically suitable radiolabel for conducting drug disposition studies, we prepared [3H]ditekiren with tritium labels in the N-methyl-histidine moi

Design and Synthesis of a Potent and Specific Renin Inhibitor with a Prolonged Duration of Action in Vivo

A structure-activity analysis of peptides containing backbone Cα-methyl and Nα-methyl modifications led to the discovery of potent renin inhibitors with high metabolic stability.In vitro, Boc-Pro-Phe-Nα-MeHis-Leuψ