103346-16-3

Basic information

• Product Name: 3-IODOBENZYLGUANIDINIUM-SULFATE
• Synonyms: 3-IODOBENZYLGUANIDINIUM-SULFATE;(3-IODOBENZYL)GUANIDINIUM SULPHATE;MIBG;N-(3-Iodobenzyl)guanidinium sulphate;3-lodobenzylguanidiniumsulfate (MIBG);1-(3-Iodobenzyl)guanidiniumsulphate;3-Iodobenzylguanidiniumsulfate (MIBG)
• CAS NO: 103346-16-3
• Molecular Formula: C8H12IN3O4S
• Molecular Weight: 373.17
• Mol File: 103346-16-3.mol

Chemical Properties

• Melting Point: 166-167°C
• Boiling Point: 382.1 °C at 760 mmHg
• Flash Point: 184.9 °C
• Appearance: /
• Vapor Pressure: 4.85E-06mmHg at 25°C
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• CAS DataBase Reference: 3-IODOBENZYLGUANIDINIUM-SULFATE(CAS DataBase Reference)
• NIST Chemistry Reference: 3-IODOBENZYLGUANIDINIUM-SULFATE(103346-16-3)
• EPA Substance Registry System: 3-IODOBENZYLGUANIDINIUM-SULFATE(103346-16-3)

Safety Data

• Hazard Codes: Xi
• Hazardous Substances Data: 103346-16-3(Hazardous Substances Data)

Usage

Uses

Used in Organic Synthesis:
3-Iodobenzylguanidinium-sulfate is used as a reagent in organic synthesis for its ability to facilitate various chemical reactions, contributing to the formation of desired organic compounds.
Used in Pharmaceutical Research:
In the pharmaceutical industry, 3-Iodobenzylguanidinium-sulfate is used as a potential antiviral agent, being studied for its effectiveness against viral infections due to its interaction with biological macromolecules.
Used in Biochemistry and Molecular Biology Research:
3-Iodobenzylguanidinium-sulfate is utilized as a tool in biochemistry and molecular biology to form stable complexes with biological macromolecules, aiding in the study of their structure, function, and interactions within biological systems.

InChI:InChI=1/C8H10IN3.H2O4S/c9-7-3-1-2-6(4-7)5-12-8(10)11;1-5(2,3)4/h1-4H,5H2,(H4,10,11,12);(H2,1,2,3,4)

Upstream product

• 1184-90-3 aminoiminomethanesulfonic acid 
• 696-40-2 3-iodobenzylamine 
• 103346-17-4 m-iodobenzylguanidine dihydrogen carbonate 
• 3718-88-5 3-iodobenzylamine hydrochloride 

Downstream Products

• 74075-13-1 (m-<¹²⁵I>iodobenzyl)guanidine 

Relevant articles and documents

Preparation method of meto-Iodobenzylguanidine

The invention relates to a preparation method of I-MIBG (meto-Iodobenzylguanidine). The method comprises the following steps: heating meto-Iodobenzylguanidine sulfate, stannous mono-sulphate, a reducing agent, copper sulfate and NaI in a boiling water bath, standing after finishing the reaction, taking a supernatant liquid, and filtering the supernatant liquid with a microfiltration membrane. Sodium thiosulfate and/or sodium thiosulfate are/is taken as the reducing agent to prepare the meto-Iodobenzylguanidine sulfate, the prepared I-MIBG is high in radiochemical purity and good in stability, and the radiochemical purity of the prepared I-MIBG is still at a relatively high level after 48 hours.

Methods for purifying radiolabelled compounds

One aspect of the present invention relates to a method of purifying radiolabelled compounds comprising a) loading onto a fluorous polymer a radiolabelled compound precursor comprising a fluoroalkyl tin moiety; b) reacting the radiolabelled compound precursor with a radiolabel delivering compound to give a radiolabelled compound, wherein the fluoroalkyl tin moiety is replaced by a radiolabel; and c) eluting the radiolabelled compound from the fluorous polymer.

Imaging agent and method of use

A new radiopharmaceutical composition for use in nuclear medicine comprises a radioiodinated meta-iodobenzylguanidine. The composition is used as an imaging agent for the heart, adrenal medulla, and tumors of the adrenal medulla and can be used for treatm