103420-78-6

Basic information

• Product Name: 1H-Indole-2-carboxamide, N-[5-(2-fluorophenyl)-2,3-dihydro-1-methyl-2-oxo-1H-1,4-benzodiazepin -3-yl]-, (S)-
• CAS NO: 103420-78-6
• Molecular Formula: C25H19FN4O2
• Molecular Weight: 426.45
• Mol File: 103420-78-6.mol

Chemical Properties

• CAS DataBase Reference: 1H-Indole-2-carboxamide, N-[5-(2-fluorophenyl)-2,3-dihydro-1-methyl-2-oxo-1H-1,4-benzodiazepin -3-yl]-, (S)-(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-Indole-2-carboxamide, N-[5-(2-fluorophenyl)-2,3-dihydro-1-methyl-2-oxo-1H-1,4-benzodiazepin -3-yl]-, (S)-(103420-78-6)
• EPA Substance Registry System: 1H-Indole-2-carboxamide, N-[5-(2-fluorophenyl)-2,3-dihydro-1-methyl-2-oxo-1H-1,4-benzodiazepin -3-yl]-, (S)-(103420-78-6)

Safety Data

• Hazardous Substances Data: 103420-78-6(Hazardous Substances Data)

Upstream product

• 58881-45-1 Indole-2-carbonyl chloride 
• 103343-68-6 (S)-3-Amino-5-(2-fluoro-phenyl)-1-methyl-1,3-dihydro-benzo[e][1,4]diazepin-2-one 

Relevant articles and documents

Methods for Drug Discovery: Development of Potent, Selective, Orally Effecive Cholecystokinin Antagonists

3-(Acylamino)-5-phenyl-2H-1,4-benzodiazepines, antagonists of the peptide hormone cholecystokinin (CCK), are described.Developed by reasoned modification of the known anxiolytic benzodiazepines, these compounds provide highly potent, orally effective ligands selective for peripheral (CCK-A) receptors, with binding affinities approaching or equaling that of the natural ligand CCK-8.The distinction between CCK-A receptors on the one hand and CNS (CCK-B), gastrin, and central benzodiazepine receptors on the other is demonstrated by using the structure-activity profiles of the new compounds.Details of the binding of these agents to CCK-A receptors are examined, and the method of development of these compounds is discussed in terms of its relevance to the general problem of drug discovery.