103440-59-1

Basic information

• Product Name: Ethanone, 1-(4-hydroxy-3-iodo-5-methoxyphenyl)-
• CAS NO: 103440-59-1
• Molecular Formula: C9H9IO3
• Molecular Weight: 292.073
• Mol File: 103440-59-1.mol

Chemical Properties

• CAS DataBase Reference: Ethanone, 1-(4-hydroxy-3-iodo-5-methoxyphenyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: Ethanone, 1-(4-hydroxy-3-iodo-5-methoxyphenyl)-(103440-59-1)
• EPA Substance Registry System: Ethanone, 1-(4-hydroxy-3-iodo-5-methoxyphenyl)-(103440-59-1)

Safety Data

• Hazardous Substances Data: 103440-59-1(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
Ethanone, 1-(4-hydroxy-3-iodo-5-methoxyphenyl)is used as a potential pharmaceutical compound for its unique structural features and functional groups. The presence of the hydroxy, iodo, and methoxy groups on the phenyl ring may contribute to its potential therapeutic applications, although further research is required to explore its specific properties and uses in drug development.

Upstream product

• 498-02-2 1-(3-methoxy-4-hydroxyphenyl)ethanone 

Downstream Products

• 2478-38-8 1-(4-hydroxy-3,5-dimethoxy-phenyl)-ethanone 
• 144978-69-8 2-bromo-1-[3-methoxy-4-hydroxy-5-iodophenyl]ethanone 
• 92287-23-5 4-Acetoxy-5-iod-3-methoxy-acetophenon 
• 3934-89-2 1-(3,4-dihydroxy-5-methoxyphenyl)-ethan-1-one 
• 245469-66-3 1-[3-methoxy-4-(4-chlorophenylthioethoxy)-5-iodophenyl]-4-(3,4,5-trimethoxyphenyl)butane-1,4-dione 
• 245469-67-4 1-[3-methoxy-4-(4-chlorophenylthioethoxy)-5-iodophenyl]-4-(3,4,5-trimethoxyphenyl)-1,4-butanediol 
• 193739-32-1 (+/-)-cis-2-[3-methoxy-4-(4-chlorophenylthioethoxy)-5-cyanophenyl]-5-(3,4,5-trimethoxyphenyl)tetrahydrofuran 
• 245469-68-5 2-[3-methoxy-4-(4-chlorophenylthioethoxy)-5-iodophenyl]-5-(3,4,5-trimethoxyphenyl)tetrahydrofuran 
• 245469-62-9 3-(N,N-dimethylamino)-1-[3-methoxy-4-(4-chlorophenylthioethoxy)-5-iodophenyl]propan-1-one 
• 245469-65-2 1-[3-methoxy-4-(4-chlorophenylthioethoxy)-5-iodophenyl]prop-2-en-1-one 
• 193739-32-1 (+/-)-trans-2-[3-methoxy-4-(4-chlorophenylthioethoxy)-5-cyanophenyl]-5-(3,4,5-trimethoxyphenyl)tetrahydrofuran 
• 245469-59-4 ethanone-1-[3-methoxy-4-(4-chlorophenylthioethoxy)-5-iodophenyl] 
• 670749-33-4 1-[3-methoxy-4-hydroxy-5-iodophenyl]-4-(3,4,5-trimethoxyphenyl)-3-(carboethoxy)-butane-1,4-dione 
• 670749-34-5 1-[3-methoxy-4-hydroxy-5-iodophenyl]-4-(3,4,5-trimethoxyphenyl)-butane-1,4-dione 

Relevant articles and documents

Efficient and sustainable laccase-catalyzed iodination of: P -substituted phenols using KI as iodine source and aerial O2 as oxidant

The laccase-catalyzed iodination of p-hydroxyarylcarbonyl- and p-hydroxyarylcarboxylic acid derivatives using KI as iodine source and aerial oxygen as the oxidant delivers the corresponding iodophenols in a highly efficient and sustainable manner with yields up to 93% on a preparative scale under mild reaction conditions.

Synthesis of (± )trans-2-[3-methoxy-4-(4-chlorophenylthioethoxy)-5-cyanophenyl]-5-(3,4, 5-trimethoxyphenyl) tetrahydrofuran

The synthesis of a potent platelet activating factor is described utilising commercially available acetovanillone and ethyl 3,4,5-trimethoxybenzoylacetate.

PHARMACEUTICAL FORMULATIONS USEFUL TO TREAT INFLAMMATORY AND IMMUNE DISORDERS

A pharmaceutical formulation is provided for the treatment of inflammatory and/or immune disorders, particularly those mediated by platelet activating factor (“PAF”) or a product of 5-lipoxygenase. The formulation, in one embodiment, is an essentially anhydrous ointment containing an active agent selected from the group consisting of 2,5-diaryl tetrahydrofurans, 2,5-diaryl tetrahydrothiophenes, 2,4-diaryl tetrahydrofurans, 2,4-diaryl tetrahydrothiophenes, 1,3-diaryl cyclopentanes, 2,4-diaryl pyrrolidines, and 2,5-diaryl pyrrolidines, and an enhancer composition containing one or more C3-18 esters such as diethyl succinate, propylene carbonate, diisopropyl adipate and glyceryl triacetate. In another embodiment, the formulation is a cream, gel, lotion, oil, or the like, containing the: active agent in crystalline form. The invention also encompasses the novel crystalline form of the active agent, and methods for using the formulations to treat individuals with inflammatory and/or immune disorders. Also encompassed is use of isopropyl alcohol (IPA) to enhance stability of the active agent and pharmaceutical formulations.

Synthesis and antimicrobial activity of 1-[3-methoxy-4-[4-chlorophenylthioethoxy]-5-iodophenyl]prop-2-ene-1-one and its intermediates

The synthesis and antimicrobial activity of 1-[3-methoxy-4-(4-chlorophenylthioethoxy)-5-iodophenyl]prop-2-ene-1-one, which is used as an important intermediate for the synthesis of 2.5-transdiaryltetrahydronfuran, are reported.

(±)-Trans-2-[3-methoxy-4-(4-chlorophenyl thioethoxy)-5-cyanophenyl]-5- (3,4,5-trimethoxyphenyl)tetrahydrofuran, a potent PAF-receptor antagonist

The synthesis of (±)-trans-2-[3-methoxy-4- (chlorophenylthioethoxyphenyl)-5-cyanophenyl]-5-(3,4,5- trimethoxyphenyl)tetrahydrofuran from commercially available acetovanillone and 3,4,5-trimethoxybenzaldehyde is described.