Dual-functional abeo-taxane derivatives destabilizing microtubule equilibrium and inhibiting NF-κB activation
Taxchinin A, with a 11(15→1)-abeo-taxane skeleton, is a major, but inactive taxoid contained in leaves of Taxus chinensis. In our design of dual-functional antitumor abeo-taxane derivatives, two fragments from antitumor agents with different molecular tar
Zhao, Yu,Su, Jia,Goto, Masuo,Morris-Natschke, Susan L.,Li, Yan,Zhao, Qin-Shi,Yao, Zhu-Jun,Lee, Kuo-Hsiung
p. 4749 - 4757
(2013/07/19)
Synthesis, cytotoxic activity, and SAR analysis of the derivatives of taxchinin A and brevifoliol
Twenty-one derivatives of taxchinin A (1) and brevifoliol (2) were synthesized and evaluated for cytotoxicity against human non-small lung cancer (A549) cell line. Nine derivatives showed potent activity with IC50 values from 0.48 to 6.22 μM. 5