Synthesis, cytotoxic activity, and SAR analysis of the derivatives of taxchinin A and brevifoliol
Twenty-one derivatives of taxchinin A (1) and brevifoliol (2) were synthesized and evaluated for cytotoxicity against human non-small lung cancer (A549) cell line. Nine derivatives showed potent activity with IC50 values from 0.48 to 6.22 μM. 5