- Hydrogenolysis of the C-O Bond of the 1,2,4-Oxadiazine Ring. Adams Platinum Hydrogenation of 3-Aryl-5,6-dihydro-5-(substituted)-methylene-4H-1,2,4-oxadiazine Derivatives
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Adams platinum hydrogenation of Z-3-aryl-5,6-dihydro-5-(substituted)methylene-4H-1,2,4-oxadiazine (1a-f) proceeds very slowly through C-O bond fission to give N-(1-substitutedcarbonyl-2-propylidene)benzamide oxime derivative 2 as the main product.In the reaction of 5-(arylcarbamoyl)methylene analogues 1d-f, 5-(arylcarbamoyl)methyl-5,6-dihydro-3-phenyl-4H-1,2,4-oxadiazine (4) and N-aryl-3-hydroxybutanamide derivative 5 are also obtained as well as compound 2.
- Kawashima, Etsuko,Takada, Toyozo,Tabei, Katsumi
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p. 1409 - 1412
(2007/10/02)
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