- Synthesis and in vitro evaluation of 5-[18F]fluoroalkyl pyrimidine nucleosides for molecular imaging of herpes simplex virus type 1 thymidine kinase reporter gene expression
-
Two novel series of 5-fluoroalkyl-2′-deoxyuridines (FPrDU, FBuDU, FPeDU) and 2′-fluoro-2′-deoxy-5-fluoroalkylarabinouridines (FFPrAU, FFBuAU, FFPeAU) that have three, four, or five methylene units (propyl, butyl, or pentyl) at C-5 were prepared and tested
- Chacko, Ann-Marie,Qu, Wenchao,Kung, Hank F.
-
body text
p. 5690 - 5701
(2009/09/29)
-
- Synthesis of 5-fluoroalkylated pyrimidine nucleosides via Negishi cross-coupling
-
(Chemical Equation Presented) 5-Fluoroalkylated pyrimidine nucleosides (1) have potential as therapeutic agents and molecular imaging agents targeting HSV1-tk suicide gene therapy. Thus, straightforward preparation of 5-fluoroalkylated nucleoside derivati
- Chacko, Ann-Marie,Qu, Wenchao,Kung, Hank F.
-
p. 4874 - 4881
(2008/12/20)
-