- Design and Synthesis of Heteroleptic Cyclometalated Iridium(III) Complexes Containing Quinoline-Type Ligands that Exhibit Dual Phosphorescence
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The design and synthesis of some cyclometalated iridium(III) complexes containing quinoline-type ligands as ancillary ligands are reported. The emission spectra of Ir(III) complexes containing a quinolinolate (6, 8, 10) moiety exhibit a single emission pe
- Kumar, Sarvendra,Hisamatsu, Yosuke,Tamaki, Yusuke,Ishitani, Osamu,Aoki, Shin
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- BIHETEROCYCLIC INHIBITORS OF ISPF FOR TREATMENT OF MICROBIAL INFECTIONS
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Provided are compounds of Formula (I) as described herein and that are useful as 2C-methyl-d-erythritol-2,3-cyclodiphosphate synthase (IspF) inhibitors. The compounds and their pharmaceutical compositions are useful in treating microbial infections in sub
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Paragraph 0080-0082
(2021/07/24)
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- Sulfonamides and sulphonyl ester of quinolines as non-acidic, nonsteroidal, anti-inflammatory agents
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Background: Quinolines are an important class of heterocyclic compounds possessing a wide range of biological activities. Previously, we had identified Schiff bases of quinoline as potential anti-inflammatory agents, thus the current work is the continuat
- Bano, Bilquees,Kanwal,Khan, Khalid Mohammed,Jabeen, Almas,Faheem, Aisha,Taha, Muhammad,Haider, Syed Moazzam,Perveen, Shahnaz
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p. 112 - 120
(2021/04/21)
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- NEUROPROTECTIVE QUINOLINE SULFONAMIDES
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Disclosed herein are methods and compositions comprising compounds capable of activating and increasing protein SUMOylation. Disclosed herein are methods and compositions comprising compounds capable of showing neuroprotective and cytoprotective effects w
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Paragraph 0038
(2020/07/07)
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- Visible Light-Promoted Photocatalytic C-5 Carboxylation of 8-Aminoquinoline Amides and Sulfonamides via a Single Electron Transfer Pathway
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An efficient photocatalytic method was developed for the remote C5-H bond carboxylation of 8-aminoquinoline amide and sulfonamide derivatives. This methodology uses in situ generated ?CBr3 radical as a carboxylation agent with alcohol and is further extended to a variety of arenes and heteroarenes to synthesize the desired carboxylated product in moderate-to-good yields. The reaction proceeding through a single electron transfer pathway was established by a control experiment, and a butylated hydroxytoluene-trapped aryl radical cation intermediate in high-resolution mass spectrometry was identified.
- Sen, Chiranjit,Sahoo, Tapan,Singh, Harshvardhan,Suresh, Eringathodi,Ghosh, Subhash Chandra
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p. 9869 - 9896
(2019/08/20)
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- Metal-Binding Pharmacophore Library Yields the Discovery of a Glyoxalase 1 Inhibitor
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Anxiety and depression are common, highly comorbid psychiatric diseases that account for a large proportion of worldwide medical disability. Glyoxalase 1 (GLO1) has been identified as a possible target for the treatment of anxiety and depression. GLO1 is a Zn2+-dependent enzyme that isomerizes a hemithioacetal, formed from glutathione and methylglyoxal, to a lactic acid thioester. To develop active inhibitors of GLO1, fragment-based drug discovery was used to identify fragments that could serve as core scaffolds for lead development. After screening a focused library of metal-binding pharmacophores, 8-(methylsulfonylamino)quinoline (8-MSQ) was identified as a hit. Through computational modeling and synthetic elaboration, a potent GLO1 inhibitor was developed with a novel sulfonamide core pharmacophore. A lead compound was demonstrated to penetrate the blood-brain barrier, elevate levels of methylglyoxal in the brain, and reduce depression-like behavior in mice. These findings provide the basis for GLO1 inhibitors to treat depression and related psychiatric illnesses.
- Perez, Christian,Barkley-Levenson, Amanda M.,Dick, Benjamin L.,Glatt, Peter F.,Martinez, Yadira,Siegel, Dionicio,Momper, Jeremiah D.,Palmer, Abraham A.,Cohen, Seth M.
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supporting information
p. 1609 - 1625
(2019/02/14)
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- Synthesis, in?vitro β-glucuronidase inhibitory potential and molecular docking studies of quinolines
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In this study synthesis and β-glucuronidase inhibitory potential of 3/5/8 sulfonamide and 8-sulfonate derivatives of quinoline (1–40) are discussed. Studies reveal that all the synthetic compounds were found to have good inhibitory activity against β-gluc
- Bano, Bilquees,Arshia,Khan, Khalid Mohammed,Kanwal,Fatima, Bibi,Taha, Muhammad,Ismail, Nor Hadiani,Wadood, Abdul,Ghufran, Mehreen,Perveen, Shahnaz
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p. 849 - 864
(2017/09/05)
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- Identifying chelators for metalloprotein inhibitors using a fragment-based approach
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Fragment-based lead design (FBLD) has been used to identify new metal-binding groups for metalloenzyme inhibitors. When screened at 1 mM, a chelator fragment library (CFL-1.1) of 96 compounds produced hit rates ranging from 29% to 43% for five matrix meta
- Jacobsen, Jennifer A.,Fullagar, Jessica L.,Miller, Melissa T.,Cohen, Seth M.
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experimental part
p. 591 - 602
(2011/03/21)
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- Sulfonamidoquinoline/palladium(II)-dimer complex as a catalyst precursor for palladium-catalyzed γ-Selective and stereospecific allyl-aryl coupling reaction between allylic acetates and arylboronic acids
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On neutral territory: A neutral palladium(II)-dimer catalyst system incorporating anionic sulfonamidoquinoline ligands is effective for the γ-selective and stereospecific allyl-aryl coupling between acyclic (E)-allylic acetates and arylboronic acids. Copy
- Makida, Yusuke,Ohmiya, Hirohisa,Sawamura, Masaya
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supporting information; experimental part
p. 410 - 414
(2011/10/03)
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- Material for luminescence element and luminescence element using the same
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A material for a luminescence element is described, which is a compound having a partial structure represented by the following formula (I): wherein Q1represents an atomic group necessary to form a 5- or 6-membered nitrogen-containing aromatic
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