Design, synthesis, and biological evaluation of glycine-based molecular tongs as inhibitors of Aβ1-40 aggregation in vitro
A series of N-terminus benzamides of glycine-based symmetric peptides, linked to m-xylylenediamine and 3,4′-oxydianiline spacers, were prepared and tested as inhibitors of β-amyloid peptide Aβ1-40 aggregation in vitro. Compounds with good anti-