- Facile carbamoylation of 3,4-dihydropyridin-2-one with N-chlorosulfonyl isocyanate
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3,4-Dihydro-2-pyridone-5-carboxylic acid amides were prepared by carbamoylation at the C-5 position of 3,4-dihydropyridin-2-one with N-chlorosulfonyl isocyanate.
- Sa?ański, Piotr,Young, Kwan Ko,Lee, Kee-In
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- MANGANESE BASED COMPLEXES AND USES THEREOF FOR HOMOGENEOUS CATALYSIS
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The present invention relates to novel manganese complexes and their use, inter alia, for homogeneous catalysis in (1) the preparation of imine by dehydrogenative coupling of an alcohol and amine; (2) C-C coupling in Michael addition reaction using nitriles as Michael donors; (3) dehydrogenative coupling of alcohols to give esters and hydrogen gas (4) hydrogenation of esters to form alcohols (including hydrogenation of cyclic esters (lactones) or cyclic di-esters (di- lactones), or polyesters); (5) hydrogenation of amides (including cyclic dipeptides, lactams, diamide, polypeptides and polyamides) to alcohols and amines (or diamine); (6) hydrogenation of organic carbonates (including polycarbonates) to alcohols or hydrogenation of carbamates (including polycarbamates) or urea derivatives to alcohols and amines; (7) dehydrogenation of secondary alcohols to ketones; (8) amidation of esters (i.e., synthesis of amides from esters and amines); (9) acylation of alcohols using esters; (10) coupling of alcohols with water and a base to form carboxylic acids; and (11) preparation of amino acids or their salts by coupling of amino alcohols with water and a base. (12) preparation of amides (including formamides, cyclic dipeptides, diamide, lactams, polypeptides and polyamides) by dehydrogenative coupling of alcohols and amines; (13) preparation of imides from diols.
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Paragraph 00396
(2017/09/05)
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- Synthesis of Cyclic Imides by Acceptorless Dehydrogenative Coupling of Diols and Amines Catalyzed by a Manganese Pincer Complex
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The first example of base-metal-catalyzed dehydrogenative coupling of diols and amines to form cyclic imides is reported. The reaction is catalyzed by a pincer complex of the earth abundant manganese and forms hydrogen gas as the sole byproduct, making the overall process atom economical and environmentally benign.
- Espinosa-Jalapa, Noel Angel,Kumar, Amit,Leitus, Gregory,Diskin-Posner, Yael,Milstein, David
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supporting information
p. 11722 - 11725
(2017/09/07)
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- Aminoheteroaryl benzamides as kinase inhibitors
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The present invention provides a compound of Formula (I) or a salt thereof; and therapeutic uses of these compounds. The present invention further provides pharmaceutical compositions comprising these compounds, and compositions comprising these compounds with a therapeutic co-agent.
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Page/Page column 583; 584; 585
(2016/02/15)
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- Direct site-selective arylation of enamides via a decarboxylative cross-coupling reaction
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An efficient Pd-catalyzed decarboxylative cross-coupling reaction of simple enamides was achieved. Depending on the choice of the nitrogen-protecting group, a site-selective synthesis of mono- or diarylated framework(s) was performed under mild conditions
- Gigant, Nicolas,Chausset-Boissarie, La?titia,Gillaizeau, Isabelle
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supporting information
p. 816 - 819
(2013/03/28)
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- PROCESS OF FORMING A CYCLIC IMIDE
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A process is provided for the synthesis of a cyclic imide. A primary amine and a diol compound are contacted in the presence of a Ruthenium (II) complex. The Ruthenium (II) catalyst includes at least one of an alicyclic ligand, an aromatic ligand, an arylalicyclic ligand, an arylaliphatic ligand and a phosphine ligand.
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Page/Page column 33
(2012/01/15)
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- Synthesis of cyclic imides from simple diols
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There's something imide so strong: Cyclic imides were synthesized from simple diols with primary amines in a single step using an in-situ-generated ruthenium catalytic system. The atom-economical and operatively simple syntheses of succinimides, phthalimides, and glutarimides, which are important building blocks in natural products and drugs, was also demonstrated. Copyright
- Zhang, Jian,Senthilkumar, Muthaiah,Ghosh, Subhash Chandra,Hong, Soon Hyeok
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supporting information; experimental part
p. 6391 - 6395
(2010/11/05)
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- Synthesis of 2-azabicyclo[4.1.0]heptanes through stereoselective cyclopropanation reactions
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Unsaturated δ-lactams are cyclopropanated with the aid of diazo compound decomposition catalysed by metal complexes. A study of the reaction conditions, stereochemical outcome and group protection is reported. The resulting bicyclic products are related to bioactive compounds. Transformation into thiolactams facilitates the separation of the different isomers obtained and the removal of the protecting group. The cyclopropanation reaction works with diverse diazo compounds. Unsaturated δ-lactams are cyclopropanated with the aid of diazo compound decomposition catalysed by metal complexes. A study of the reaction conditions, stereochemical outcome and group protection isreported. Transformation into thiolactams assists in separation of the different isomers obtained and removal of the protecting group.
- Suarez Del Villar, Irene,Gradillas, Ana,Perez-Castells, Javier
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experimental part
p. 5850 - 5862
(2011/03/17)
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- Enantioselective synthesis of the R-enantiomer of the feeding deterrent (S)-ypaoamide
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(Chemical Equation Presented) The enantioselective synthesis of the R-enantiomer of the marine natural product (S)-ypaoamide (5) is reported. The synthesis features both a flexible racemization-free approach to the 5-substituted 3-pyrrolin-2-one segment,
- Chen, Jie,Huang, Pei-Qiang,Queneau, Yves
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supporting information; experimental part
p. 7457 - 7463
(2010/01/06)
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- Efficient preparation and processing of the 4-methoxybenzyl (PMB) group for phenolic protection using ultrasound
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(Chemical Equation Presented) Power ultrasound efficiently facilitates the rapid preparation and reaction of 4-methoxybenzyl chloride (PMB-Cl) 1 in providing protected phenolic ether intermediates for organic synthesis. Using two-phase systems in both the ultrasound-promoted preparation and reactions of PMB-Cl, typical runs produce PMB-protected products within 15 min. When compared with nonsonicated control reactions, the results demonstrate clear advantage in terms of efficiency when the protocol is applied to the mild and selective protection of various multisubstituted phenols including sensitive phenolic aldehydes.
- Luzzio, Frederick A.,Chen, Juan
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p. 5621 - 5624
(2008/12/21)
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