Synthesis of novel structurally simplified estrogen analogues
A library of 17 novel estrogen analogues 3 and 4 containing different substituents at rings A and D (steroid nomenclature) was prepared in a five- to seven-step synthesis. The key transformation is a Sonogashira-coupling of cyclic vinyl iodides of type 7
Tietze, Lutz F.,Vock, Carsten A.,Krimmelbein, Ilsa K.,Wiegand, J. Matthias,Nacke, Linda,Ramachandar, Tokala,Islam, Kazi M. D.,Gatz, Christiane
experimental part
p. 3670 - 3679
(2009/04/11)
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