- Gas-liquid flow hydrogenation of nitroarenes: Efficient access to a pharmaceutically relevant pyrrolobenzo[1,4]diazepine scaffold
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Using a Tube-in-Tube device based on the amorphous Teflon AF-2400 fluoropolymer, a series of nitroarenes was hydrogenated to afford the corresponding aniline compounds. The system was then applied to the construction of a pyrrolobenzo[1,4]diazapene scaffold through a tandem hydrogenation-condensation-hydrogenation sequence.
- Dimitriou, Eleni,Jones, Richard H.,Pritchard, Robin G.,Miller, Gavin J.,O'Brien, Matthew
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p. 6795 - 6803
(2018/10/15)
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- 2-Aralkynyl and 2-Heteroalkynyl Derivatives of Adenosine-5'-N-ethyluronamide as Selective A2a Adenosine Receptor Agonists
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A series of new 2-aralkynyl and 2-heteroaralkynyl derivatives of NECA were synthesized and studied in binding and functional assays to assess their potency for the A2a compared to A1 adenosine receptors.Compounds bearing an aromatic
- Cristalli, Gloria,Camaioni, Emidio,Vittori, Sauro,Volpini, Rosaria,Borea, Pier Andrea,et al.
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p. 1462 - 1472
(2007/10/02)
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- Spirodienones. Part 5. The Synthesis and Reactions of N-Sulphonylcyclohexadienimines
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The anodic or chemical oxidation of para-substituted sulphonanilides gives 4,4-disubstituted N-sulphonylcyclohexadienimines, which, from appropriately substituted anilines, may be spirocyclic.The scope and limitations of the synthesis are described, and mechanism proposed.The selective hydrolysis of the dienimines to the corresponding dienones provides a convenient route to the latter compounds.The reaction of some of the dienimines with dienes is discussed.
- Coutts, Ian G. C.,Culbert, Nicholas J.,Edwards, Mark,Hadfield, John A.,Musto, Donald R.,et al.
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p. 1829 - 1836
(2007/10/02)
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