103854-62-2

Basic information

• Product Name: 8-methoxyquinoline-4-carbaldehyde
• Synonyms: 8-methoxyquinoline-4-carbaldehyde
• CAS NO: 103854-62-2
• Molecular Formula: C₁₁H₉NO₂
• Molecular Weight: 187.19466
• Mol File: 103854-62-2.mol

Chemical Properties

• Appearance: /
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• CAS DataBase Reference: 8-methoxyquinoline-4-carbaldehyde(CAS DataBase Reference)
• NIST Chemistry Reference: 8-methoxyquinoline-4-carbaldehyde(103854-62-2)
• EPA Substance Registry System: 8-methoxyquinoline-4-carbaldehyde(103854-62-2)

Safety Data

• Hazardous Substances Data: 103854-62-2(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical and Agrochemical Industries:
8-methoxyquinoline-4-carbaldehyde is used as an intermediate in the synthesis of pharmaceuticals and agrochemicals for its ability to contribute to the development of new drugs and pesticides.
Used in Materials Science:
8-methoxyquinoline-4-carbaldehyde is used as a fluorescent probe for detecting metal ions, capitalizing on its chemical properties to create sensitive and selective detection methods.
Used in Organic Material Development:
8-methoxyquinoline-4-carbaldehyde serves as a building block for the development of organic materials with specific properties, such as luminescent materials or those with tailored electronic characteristics, due to its structural features and reactivity.

Upstream product

• 61703-95-5 8-methoxy-4-methylquinoline 
• 90-04-0 2-methoxy-phenylamine 
• 3846-73-9 4-methylquinolin-8-ol 

Relevant articles and documents

Direct access of the chiral quinolinyl core of cinchona alkaloids via a br?nsted acid and chiral amine co-catalyzed chemo- and enantioselective α-alkylation of quinolinylmethanols with enals

A strategy for the facile construction of the chiral quinolinylmethanolic structure, a core featured in cinchona alkaloids, is reported. A new reactivity is harnessed by TfOH-promoted chemoselective activation of α-C-H over O-H bond in quinolinylmethanols. The new reactivity is successfully engineered with an iminium catalysis in a synergistic manner to create a powerful conjugate addition-cyclization cascade process for synthesis of chiral quinoline derived π-butyrolactones in good yields and with good to excellent enantioselectivities. The method enables the first total synthesis of natural product broussonetine in three steps.

AROYLQUINOLINE COMPOUNDS

A serious of nitro heterocyclic derivatives including a structure of formula (I) are provided. In formula (I), P, Q and R1 to R8 are defined in the specification. The derivatives disclosed in the present invention are characterized in inhibiting tubulin p

5-Amino-2-Aroylquinolines as highly potent tubulin polymerization inhibitors

A series of aroylquinoline derivatives were synthesized and evaluated for anticancer activity. 5-Amino6-methoxy-2-aroylquinoline 15 showed more potent antiproliferative activity (IC50 values ranging from 0.2 to 0.4 nM) as compared to la (combretastatin A-4) (IC50 = 1-9-835 nM) against various human cancer cell lines and a MDR-resistant cancer cell line. Compound 15 (IC50 = 1-6 μM) exhibited more potent inhibition of tubulin polymerization than la (IC50 = 2.1 μM) and showed strong binding property to the colchicine binding site of microtubules.