1038919-35-5

Basic information

• Product Name: N-Ethyl-N-Methy-L-alanine
• Synonyms: N-Ethyl-N-Methy-L-alanine
• CAS NO: 1038919-35-5
• Molecular Formula: C₆H₁₃NO₂
• Molecular Weight: 131
• Mol File: 1038919-35-5.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: N-Ethyl-N-Methy-L-alanine(CAS DataBase Reference)
• NIST Chemistry Reference: N-Ethyl-N-Methy-L-alanine(1038919-35-5)
• EPA Substance Registry System: N-Ethyl-N-Methy-L-alanine(1038919-35-5)

Safety Data

• Hazardous Substances Data: 1038919-35-5(Hazardous Substances Data)

Upstream product

• 1038919-32-2 (S)-2-((benzyloxycarbonyl)(ethyl)amino)propanoic acid 
• 50-00-0 formaldehyd 

Downstream Products

• 1105044-56-1 (2S,2'S)-N,N'-[(1S,2S)-1,2-diphenylethane-1,2-diyl] bis{2-[ethyl(methyl)amino]propanamide} 

Relevant articles and documents

POLYCYCLIC TLR7/8 ANTAGONISTS AND USE THEREOF IN THE TREATMENT OF IMMUNE DISORDERS

The present invention relates to compounds of Formula (I) and pharmaceutically acceptable compositions thereof, useful as toll-like receptor 7/8 (TLR7/8) antagonists. In Formula (I), Ring A is aryl or heteroaryl; Ring B is aryl or heteroary; and X is C(R4)2, O, NR4, S, S(R4), or S(R4)2.

Synthesis of N-alkyl-N-methyl amino acids. Scope and limitations of base-induced N-alkylation of Cbz-amino acids

The reaction of N-benzyloxycarbonyl derivatives of aliphatic amino acids with NaH/alkyl iodides gave the corresponding N-Cbz-N-alkyl derivatives in good to high yields. The scope and limitations of this simple N-alkylation reaction were investigated as a convenient and flexible attempt to prepare unsymmetrically N,N-diprotected α-amino acids. The procedure is based on the N-alkylation of N-carbamoyl amino acids, a one-pot deprotection/protection sequence without extensive purification of the products. Protection of the carboxyl function is not required while the starting materials are inexpensive and commercially available.