103923-00-8

Basic information

• Product Name: 2-BROMO-6-PIPERIDIN-1-YLMETHYL-PYRIDINE
• Synonyms: 2-BROMO-6-PIPERIDIN-1-YLMETHYL-PYRIDINE
• CAS NO: 103923-00-8
• Molecular Formula: C₁₁H₁₅BrN₂
• Molecular Weight: 255.15
• Mol File: 103923-00-8.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2-BROMO-6-PIPERIDIN-1-YLMETHYL-PYRIDINE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-BROMO-6-PIPERIDIN-1-YLMETHYL-PYRIDINE(103923-00-8)
• EPA Substance Registry System: 2-BROMO-6-PIPERIDIN-1-YLMETHYL-PYRIDINE(103923-00-8)

Safety Data

• Hazardous Substances Data: 103923-00-8(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
2-BROMO-6-PIPERIDIN-1-YLMETHYL-PYRIDINE is used as a key intermediate in the synthesis of various pharmaceutical compounds. Its versatile reactivity allows for the formation of different chemical entities, contributing to the development of new drugs with potential therapeutic applications.
Used in Agrochemical Industry:
In the agrochemical sector, 2-BROMO-6-PIPERIDIN-1-YLMETHYL-PYRIDINE is utilized as a building block for the synthesis of agrochemicals. Its ability to undergo various chemical reactions enables the creation of compounds with pesticidal, herbicidal, or other agricultural applications, enhancing crop protection and yield.
Used in Fine Chemicals Industry:
2-BROMO-6-PIPERIDIN-1-YLMETHYL-PYRIDINE is employed as a valuable intermediate in the production of fine chemicals. Its structural features and reactivity make it suitable for the synthesis of specialty chemicals used in various industries, such as fragrances, dyes, and other high-value applications.
Potential Future Applications:
Given its unique structural features and reactivity, 2-BROMO-6-PIPERIDIN-1-YLMETHYL-PYRIDINE may have potential applications as a drug or a pharmacological tool in the future. Its ability to interact with various biological targets and modulate signaling pathways could lead to the discovery of new therapeutic agents or probes for understanding disease mechanisms.

Upstream product

• 110-89-4 piperidine 
• 34160-40-2 6-bromo-2-pyridinecarbaldehyde 

Downstream Products

• 1228660-10-3 1-(4-(6-(piperidin-1-ylmethyl)pyridin-2-yl)benzyl)-3-(2,2,2-trifluoroethyl)imidazolidine-2,4-dione 
• 1228660-02-3 3-cyclobutyl-1-(4-(6-(piperidin-1-ylmethyl)pyridin-2-yl)benzyl)imidazolidine-2,4-dione 
• 1228659-84-4 3-isopropyl1-(4-(6-(piperidin-1-ylmethyl)pyridin-2-yl)benzyl)imidazolidine-2,4-dione 
• 1228659-67-3 3-cyclopropylmethyl-1-(4-(6-(piperidin-1-ylmethyl)pyridin-2-yl)benzyl)imidazolidine-2,4-dione 
• 1228659-64-0 3-(2,2-difluoroethyl)-1-(4-(6-(piperidin-1-ylmethyl)pyridin-2-yl)benzyl)imidazolidine-2,4-dione 
• 1228659-58-2 1-(4-(6-(piperidin-1-ylmethyl)pyridin-2-yl)benzyl)-3-propylimidazolidine-2,4-dione 
• 1338056-01-1 3-methyl-1-(4-(6-(piperidin-1-ylmethyl)pyridin-2-yl)benzyl)imidazolidine-2,4-dione 
• 1228659-38-8 3-isobutyl-1-(4-(6-(piperidin-1-ylmethyl)pyridin-2-yl)benzyl)imidazolidine-2,4-dione 
• 1228660-80-7 4-(6-(piperidin-1-ylmethyl)pyridin-2-yl)benzaldehyde 

Relevant articles and documents

Discovery and optimization of 1-(4-(Pyridin-2-yl)benzyl)imidazolidine-2,4- dione derivatives as a novel class of selective cannabinoid CB2 receptor agonists

Here, we report the identification and optimization of 1-(4-(pyridin-2-yl) benzyl)imidazolidine-2,4-dione derivatives as a novel chemotype with selective cannabinoid CB2 receptor agonist activity. 1 is a potent and selective cannabinoid CB2 receptor agonist (hCB2 pEC50 = 8.6). The compound was found to be metabolically unstable, which resulted in low oral bioavailability in rat (Fpo = 4%) and possessed off-target activity at the hERG ion channel (pKi = 5.5). Systematic modification of physicochemical properties, such as lipophilicity and basicity, was used to optimize the pharmacokinetic profile and hERG affinity of this novel class of cannabinoid CB2 receptor agonists. This led to the identification of 44 as a potent, selective, and orally bioavailable cannabinoid CB2 receptor agonist (hCB2 pEC50 = 8.0; hERG pKi po = 100%), which was active in a rat spinal nerve ligation model of neuropathic pain.

1-(4-(PYRIDIN-2-YL)BENZYL)IMIDAZOLIDINE-2,4-DIONE DERIVATIVES

The invention relates to 1-(4-(pyridin-2-yl)benzyl)imidazolidine-2,4-dione derivative having the general Formula I wherein R1 is H, (C1-6)alkyl (optionally substituted with oxo, (C1-3)alkyloxy, (C1-3)alkyloxycar

Dual serotonin transporter inhibitor/histamine H3 antagonists: Development of rigidified H3 pharmacophores

A series of tetrahydroisoquinolines acting as dual serotonin transporter inhibitor/histamine H3 antagonists is described. The introduction of polar aromatic spacers as part of the histamine H3 pharmacophore was explored. A convergent synthesis of the final products allowing late stage introduction of the aromatic side chain was developed. In vitro and in vivo data are discussed.

Non-Imidazole heterocyclic compounds

Certain non-imidazole heterocyclic compounds are histamine H3 modulators useful in the treatment of histamine H3 receptor mediated diseases.