103977-87-3

Basic information

• Product Name: 2-fluoro-5-nitro-1-phenylbenzene
• CAS NO: 103977-87-3
• Molecular Weight: 217.199
• Mol File: 103977-87-3.mol

Chemical Properties

• CAS DataBase Reference: 2-fluoro-5-nitro-1-phenylbenzene(CAS DataBase Reference)
• NIST Chemistry Reference: 2-fluoro-5-nitro-1-phenylbenzene(103977-87-3)
• EPA Substance Registry System: 2-fluoro-5-nitro-1-phenylbenzene(103977-87-3)

Safety Data

• Hazardous Substances Data: 103977-87-3(Hazardous Substances Data)

Upstream product

• 350-30-1 3-chloro-4-fluoronitrobenzene 
• 98-80-6 phenylboronic acid 
• 369-36-8 6-fluoro-3-nitroaniline 
• 110-46-3 isopentyl nitrite 
• 108-86-1 bromobenzene 
• 7304-32-7 2-fluoro-5-nitrobenzoic acid 
• 71-43-2 benzene 

Downstream Products

• 103977-88-4 4-fluoro-3-phenylaniline 
• 1613189-25-5 C₃₅H₃₈N₄O₄ 
• 1613189-40-4 C₄₈H₅₈N₄O₄Si 

Relevant articles and documents

Silver-catalyzed arylation of (hetero)arenes by oxidative decarboxylation of aromatic carboxylic acids

A long-standing challenge in Minisci reactions is achieving the arylation of heteroarenes by oxidative decarboxylation of aromatic carboxylic acids. To address this challenge, the silver-catalyzed intermolecular Minisci reaction of aromatic carboxylic acids was developed. With an inexpensive silver salt as a catalyst, this new reaction enables a variety of aromatic carboxylic acids to undergo decarboxylative coupling with electron-deficient arenes or heteroarenes regardless of the position of the substituents on the aromatic carboxylic acid, thus eliminating the need for ortho-substituted aromatic carboxylic acids, which were a limitation of previously reported methods.

Dialkylimidazole inhibitors of Trypanosoma cruzi sterol 14α-demethylase as anti-Chagas disease agents

New dialkylimidazole based sterol 14α-demethylase inhibitors were prepared and tested as potential anti-Trypanosoma cruzi agents. Previous studies had identified compound 2 as the most potent and selective inhibitor against parasite cultures. In addition, animal studies had demonstrated that compound 2 is highly efficacious in the acute model of the disease. However, compound 2 has a high molecular weight and high hydrophobicity, issues addressed here. Systematic modifications were carried out at four positions on the scaffold and several inhibitors were identified which are highly potent (EC50 1 nM) against T. cruzi in culture. The halogenated derivatives 36j, 36k, and 36p, display excellent activity against T. cruzi amastigotes, with reduced molecular weight and lipophilicity, and exhibit suitable physicochemical properties for an oral drug candidate.

Oxidizing hair coloring agents containing 2,5-diamino-1-phenylbenzene derivatives and novel 2,5-diamino-1-phenylbenzene derivatives

The object of the present patent application are agents for the oxidative coloring of keratin fibers, particularly hair, based on a developer-coupler combination, characterized in that they contain as the developer at least one 2,5-diamino-1-phenylbenzene derivative of general formula and novel 2,5-diamino-1-phenylbenzene derivatives of formula (I) wherein at least one of the R1 to R10 radicals is different from hydrogen.

Antibiotic derivatives of 7-phenyl-1,4-dihydro-4-oxo-3-quinolinecarboxylic acids

1-Substituted-6-fluoro-7-aryl-(8-fluoro)-1,4-dihydroquinol-4-one 3-carboxylic acids having antibacterial activity are prepared by reacting the corresponding alkyl 1-substituted-6-fluoro-7-bromo-(8-fluoro)-1,4-dihydroquinol-4-one-3-carboxylate with an arylmetallic compound and hydrolyzing the ester formed.