Two approaches toward the total synthesis of cytotoxic polyketide natural product (+)-crocacin C (1) are described. The first approach, which was ultimately unsuccessful, was replaced altogether with a second that afforded target 1 in 10 linear steps from commercially available Evans' chiral propionimide (5% overall yield). No protecting groups were utilized in the total synthesis of 1.
Sirasani, Gopal,Paul, Tapas,Andrade, Rodrigo B.
experimental part
p. 3648 - 3655
(2010/08/03)
Concise total synthesis of (+)-crocacin C
(Chemical Equation Presented) The cytotoxic natural product (+)-crocacin C (1) has been synthesized in 10 linear steps from commercially available Evans' chiral propionimide in 5% overall yield (8 steps from Evans' chiral dipropionate synthon). No protect
Sirasani, Gopal,Paul, Tapas,Andrade, Rodrigo B.
p. 6386 - 6388
(2008/12/22)
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