1041644-31-8

Basic information

• Product Name: C₁₆H₁₈ClFN₂O
• CAS NO: 1041644-31-8
• Molecular Weight: 308.783
• Mol File: 1041644-31-8.mol

Chemical Properties

• CAS DataBase Reference: C₁₆H₁₈ClFN₂O(CAS DataBase Reference)
• NIST Chemistry Reference: C₁₆H₁₈ClFN₂O(1041644-31-8)
• EPA Substance Registry System: C₁₆H₁₈ClFN₂O(1041644-31-8)

Safety Data

• Hazardous Substances Data: 1041644-31-8(Hazardous Substances Data)

Upstream product

• 1041644-47-6 C₉H₁₃NO₂ 
• 15205-15-9 2-chloro-6-fluorobenzyl amine 

Relevant articles and documents

Structure-activity relationship and liver microsome stability studies of pyrrole necroptosis inhibitors

Necroptosis is a regulated caspase-independent cell death pathway resulting in morphology reminiscent of passive non-regulated necrosis. Several diverse structure classes of necroptosis inhibitors have been reported to date, including a series of [1,2,3]thiadiazole benzylamide derivatives. However, initial evaluation of mouse liver microsome stability indicated that this series of compounds was rapidly degraded. A structure-activity relationship (SAR) study of the [1,2,3]thiadiazole benzylamide series revealed that increased mouse liver microsome stability and increased necroptosis inhibitory activity could be accomplished by replacement of the 4-cyclopropyl-[1,2,3]thiadiazole with a 5-cyano-1-methylpyrrole. In addition, the SAR and the cellular activity profiles, utilizing different cell types and necroptosis-inducing stimuli, of representative [1,2,3]thiadiazole and pyrrole derivatives were very similar suggesting that the two compound series inhibit necroptosis in the same manner.