1041644-40-9

Basic information

• Product Name: C₁₄H₁₁ClFN₃O
• CAS NO: 1041644-40-9
• Molecular Weight: 291.712
• Mol File: 1041644-40-9.mol

Chemical Properties

• CAS DataBase Reference: C₁₄H₁₁ClFN₃O(CAS DataBase Reference)
• NIST Chemistry Reference: C₁₄H₁₁ClFN₃O(1041644-40-9)
• EPA Substance Registry System: C₁₄H₁₁ClFN₃O(1041644-40-9)

Safety Data

• Hazardous Substances Data: 1041644-40-9(Hazardous Substances Data)

Upstream product

• 557-21-1 zinc(II) cyanide 
• 1041644-49-8 C₁₃H₁₁BrClFN₂O 
• 15205-15-9 2-chloro-6-fluorobenzyl amine 

Relevant articles and documents

Structure-activity relationship and liver microsome stability studies of pyrrole necroptosis inhibitors

Necroptosis is a regulated caspase-independent cell death pathway resulting in morphology reminiscent of passive non-regulated necrosis. Several diverse structure classes of necroptosis inhibitors have been reported to date, including a series of [1,2,3]thiadiazole benzylamide derivatives. However, initial evaluation of mouse liver microsome stability indicated that this series of compounds was rapidly degraded. A structure-activity relationship (SAR) study of the [1,2,3]thiadiazole benzylamide series revealed that increased mouse liver microsome stability and increased necroptosis inhibitory activity could be accomplished by replacement of the 4-cyclopropyl-[1,2,3]thiadiazole with a 5-cyano-1-methylpyrrole. In addition, the SAR and the cellular activity profiles, utilizing different cell types and necroptosis-inducing stimuli, of representative [1,2,3]thiadiazole and pyrrole derivatives were very similar suggesting that the two compound series inhibit necroptosis in the same manner.