Direct sequential C3 and C1 arylation reaction of imidazo[1,5-a]pyridine catalyzed by a 1,10-phenanthrolinepalladium complex
The direct sequential arylation reaction at the C3 and C1 positions of imidazo[1,5-a]pyridines with a variety of aryl iodides catalyzed by [Pd(phen)2](PF6)2 is described. The reaction of unsubstituted imidazo[1,5-a]pyridine with various aryl iodides proceeded selectively at the C3 position to exclusively give the corresponding C3-arylated products. The one-pot double-arylation reaction at the C3 and C1 positions of unsubstituted imidazo[1,5-a]pyridine with different aryl groups was also achieved.
Palladium-catalyzed highly regioselective C-3 arylation of imidazo[1,5-a]pyridine
A direct palladium-catalyzed highly regioselective C-3 arylation of imidazo[1,5-a]pyridine with aryl bromides has been developed. This reaction is quite general with respect to the aryl or hetaryl bromide.
Huang, Chunhui,Giokaris, Alexandros,Gevorgyan, Vladimir
supporting information; experimental part
p. 1053 - 1054
(2011/12/05)
1H- and 13C-NMR spectra of 3-aryl-2-azaindolizines
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Ashauer,Wolff,Haller
p. 43 - 52
(2007/10/02)
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