cas 104217-23-4, 4-AMINO-6-METHOXY-2-METHYLQUINOLINE | Articles data ｜lookchem

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104217-23-4

Articles about 104217-23-4Total 3 be found

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Design, synthesis and docking studies of quinoline-oxazolidinone hybrid molecules and their antitubercular properties
New series of quinoline-oxazolidinone hybrid molecules were synthesized based on the preliminary docking studies. All the newly synthesized compounds were characterized by spectral analyses. The newly synthesized compounds were screened for their antimycobacterial properties based on the promising preliminary antibacterial screening results. Amongst tested compounds, compounds 8a, 8j and 13a were active at 0.65 μg/mL against Mycobacterium tuberculosis H37Rv strain. The mode of action of these active compounds was carried out by docking of receptor enoyl-ACP reductase with newly synthesized candidate ligands 8a, 8j and 13a. These compounds exhibited well established bonds with one or more amino acids in the receptor active pocket. From the docking studies, compound 8j was considered to be the best inhibitor.
Thomas,Adhikari, Airody Vasudeva,Chowdhury, Imran H.,Sandeep,Mahmood,Bhattacharya,Sumesh
experimental part
p. 4834 - 4845
(2011/11/12)

Potent DNA-directed alkylating agents: Synthesis and biological activity of phenyl N-mustard-quinoline conjugates having a urea or hydrazinecarboxamide linker
A series of N-mustard-quinoline conjugates bearing a urea or hydrazinecarboxamide linker was synthesized for antitumor evaluation. The in vitro cytotoxicity studies revealed that compounds with hydrazinecarboxamide linkers were generally more cytotoxic th
Kakadiya, Rajesh,Dong, Huajin,Kumar, Amit,Narsinh, Dodia,Zhang, Xiuguo,Chou, Ting-Chao,Lee, Te-Chang,Shah, Anamik,Su, Tsann-Long
supporting information; experimental part
p. 2285 - 2299
(2010/06/14)

Microwave-assisted synthesis of 4-quinolylhydrazines followed by nickel boride reduction: a convenient approach to 4-aminoquinolines and derivatives
Nickel(II) chloride/sodium borohydride combination was employed for the reduction of 4-hydrazinoquinoline derivatives to the corresponding anilines. This reductive protocol was efficiently applied for the reductive cleavage of monosubstituted hydrazines. We described herein the microwave-assisted synthesis of 4-hydrazinoquinolines, which furnished a high yielding and rapid two-step procedure for the synthesis, under mild conditions, of 4-aminoquinolines as antimalarial precursors.
Gemma, Sandra,Kukreja, Gagan,Tripaldi, Pierangela,Altarelli, Maria,Bernetti, Matteo,Franceschini, Silvia,Savini, Luisa,Campiani, Giuseppe,Fattorusso, Caterina,Butini, Stefania
p. 2074 - 2077
(2008/09/18)

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Chemical Properties

Melting Point: 211-213 °C
Boiling Point: 366 °C at 760 mmHg
Flash Point:175.2 °C
Density: 1.181 g/cm³
Vapor Pressure: 1.51E-05mmHg at 25°C
Refractive Index: 1.647
PKA: 9.45±0.50(Predicted)
PSA: 48.14000
LogP: 2.71520

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