- Asymmetric synthesis of tetracyclic benzo[a]quinolizidine targets
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(Chemical Equation Presented) We report a novel, facile, and asymmetric approach for the synthesis of polycyclic benzo[a]quinolizidine targets. In the formation of more functionalized derivatives, we have observed the generation of an iminium ether salt intermediate, formed during an unprecedented retro-Diels-Alder/N-acyliminium cyclization cascade. The iminium ether intermediate was isolated in good yield, characterized by X-ray crystallography, and subsequently applied as a synthetic building block.
- Allin, Steven M.,Gaskell, Sean N.,Elsegood, Mark R. J.,Martin, William P.
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