- Small, non-peptide C5a receptor antagonists: Part 1
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The optimisation of a series of amides for C5a receptor binding and functional activity, and physicochemical properties is described. The initial hit, 1 (IC50 1 μM), was discovered during high throughput screening, from which highly potent C5a receptor antagonists (e.g. 14, IC50 5 nM) were developed.
- Blagg, Julian,Mowbray, Charles,Pryde, David C.,Salmon, Gary,Schmid, Esther,Fairman, David,Beaumont, Kevin
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scheme or table
p. 5601 - 5604
(2009/06/18)
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