- Cyclodextrin derivative inclusion compound for treating pancreatic cancer
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The invention relates to a cyclodextrin derivative inclusion compound for treating the pancreatic cancer. The existing ways of two active ingredients in the inclusion compound are different, wherein gemcitabine is bonded to a beta-cyclodextrin derivative in a chemical bonding mode first, and then the beta-cyclodextrin derivative further includes erlotinib to form a drug-loaded inclusion compound.Compared with a conventional cyclodextrin inclusion compound, and the beta-cyclodextrin derivative inclusion compound can constantly release the erlotinib and the gemcitabine in the body, so that theerlotinib and the gemcitabine maintain within the effective effect concentration range in the blood for a long time. Therefore, by means of the beta-cyclodextrin derivative inclusion compound, the drug combination curative effect can be obviously improved, and an unexpected excellent effect is generated.
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Paragraph 0032; 0038-0040
(2018/04/21)
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- New insights into poly(lactic- co -glycolic acid) microstructure: Using repeating sequence copolymers to decipher complex NMR and thermal behavior
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Sequence, which Nature uses to spectacular advantage, has not been fully exploited in synthetic copolymers. To investigate the effect of sequence and stereosequence on the physical properties of copolymers, a family of complex isotactic, syndiotactic, and atactic repeating sequence poly(lactic-co-glycolic acid) copolymers (RSC PLGAs) were prepared and their NMR and thermal behavior was studied. The unique suitability of polymers prepared from the bioassimilable lactic and glycolic acid monomers for biomedical applications makes them ideal candidates for this type of sequence engineering. Polymers with repeating units of LG, GLG and LLG (L = lactic, G = glycolic) with controlled and varied tacticities were synthesized by assembly of sequence-specific, stereopure dimeric, trimeric, and hexameric segmer units. Specifically labeled deuterated lactic and glycolic acid segmers were likewise prepared and polymerized. Molecular weights for the copolymers were in the range Mn = 12-40 kDa by size exclusion chromatography in THF. Although the effects of sequence-influenced solution conformation were visible in all resonances of the 1H and 13C NMR spectra, the diastereotopic methylene resonances in the 1H NMR (CDCl3) for the glycolic units of the copolymers proved most sensitive. An octad level of resolution, which corresponds to an astounding 31-atom distance between the most separated stereocenters, was observed in some mixed sequence polymers. Importantly, the level of sensitivity of a particular NMR resonance to small differences in sequence was found to depend on the sequence itself. Thermal properties were also correlated with sequence.
- Stayshich, Ryan M.,Meyer, Tara Y.
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supporting information; experimental part
p. 10920 - 10934
(2010/09/17)
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