Asymmetric synthesis of the optically active piperidine alkaloid (+)-β-conhydrine
A new approach for the stereoselective synthesis of the piperidine alkaloid (+)-β-conhydrine based upon a highly diastereoselective 1,2-nucleophilic addition reaction onto a diastereopure hydrazone and ring-closing metathesis as the key steps has been developed.
Lebrun, Stephane,Couture, Axel,Deniau, Eric,Grandclaudon, Pierre