1043601-53-1

Basic information

• Product Name: 6-Fluoro-1H-indole-3-carbonitrile
• Synonyms: 6-Fluoro-1H-indole-3-carbonitrile;6-Fluoro-3-carbonitrile;1H-INDOLE-3-CARBONITRILE, 6-FLUORO-
• CAS NO: 1043601-53-1
• Molecular Formula: C9H5FN2
• Molecular Weight: 160.1478032
• EINECS: -0
• Mol File: 1043601-53-1.mol

Chemical Properties

• Appearance: /
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 6-Fluoro-1H-indole-3-carbonitrile(CAS DataBase Reference)
• NIST Chemistry Reference: 6-Fluoro-1H-indole-3-carbonitrile(1043601-53-1)
• EPA Substance Registry System: 6-Fluoro-1H-indole-3-carbonitrile(1043601-53-1)

Safety Data

• Hazardous Substances Data: 1043601-53-1(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
6-Fluoro-1H-indole-3-carbonitrile is used as a key building block for the production of various pharmaceutical products. Its unique structure allows it to be a valuable intermediate in the synthesis of bioactive compounds, contributing to the development of new drugs with potential therapeutic applications.
Used in Organic Synthesis:
In the field of organic chemistry, 6-Fluoro-1H-indole-3-carbonitrile serves as an important intermediate. Its presence in the synthesis process can lead to the creation of a wide range of chemical entities, expanding the scope of chemical research and development.
Used in Research and Development:
6-Fluoro-1H-indole-3-carbonitrile is also utilized in research and development settings, where its properties and reactivity are explored to understand its potential in creating novel chemical entities and advancing scientific knowledge in organic chemistry.

Upstream product

• 2795-41-7 6-fluoro-1H-indole-3-carbaldehyde 
• 399-51-9 6-fluoro-1H-indole 
• 1261025-10-8 C₉H₇FN₂O 

Relevant articles and documents

An investigation into the substituent effect of halogen atoms on the crystal structures of indole-3-carboxylic acid (ICA)

An investigation into the substituent effect of halogen atoms (F, Cl, Br) on the crystal structure of indole-3-carboxylic acid (ICA) was prepared in this work. The investigation was done through the aspect of crystal structure, intermolecular interactions and π...π stacking motifs with the assistance of infrared spectra, elemental analyses, NMR spectra, differential scanning calorimetry (DSC), thermogravimetric analyses (TGA) and hot stage microscopy (HSM) measurements. The results revealed that the different kinds of halogen atoms and the different substituted positions have a significant effect on the crystal structures, molecular π...π stacking motifs and the kinds of intermolecular interactions. We further correlated the melting points of the ICAs with the H-H, O-H and X-H (X = F, Cl, Br) interactions, and found a positive correlation between them.

(AZA)INDOLE DERIVATIVE AND USE THEREOF FOR MEDICAL PURPOSES

The present invention provides compounds useful as agents for the prevention or treatment of a disease associated with abnormal serum uric acid level which has a uricosuric activity or the like. The present invention relates to (aza)indole derivatives represented by the following general formula (I) having xanthine oxidase inhibitory activities and useful as agents for the prevention or treatment of a disease associated with abnormality of serum uric acid level, prodrugs thereof, or salts thereof. In the formula (I), T represents nitro or cyano and the like; ring J represents aryl or heteroaryl and the like; Q represents carboxy or 5-tetazolyl and the like; Y represents H, OH, NH2, halogen, nitro, alkyl, alkoxy and the like; X1, X2 and X3 independently represent CR2 or N; R1 and R2 independently represent halogen, cyano, haloalkyl, A-D-E-G, -N(-D-E-G)2 and the like, in the formula, A represents a single bond, O, S and the like; D and G independently represent optionally substituted alkylene, cycloalkylene, heterocycloalkylene, arylene, heteroarylene and the like; E represents a single bond, O, S, COO, SO2 and the like.