Simple preparation of N-protected chiral-amino alkyl thiols from corresponding iodides employing sodium trithiocarbonate
A simple protocol for the preparation of N-protected amino alkyl thiols is reported that employs a reaction of sodium trithiocarbonate (Na 2CS3) with N-protected amino alkyl iodides. Na 2CS3 is easy to prepare and the protocol circumvents the use of strong bases and multiple steps. All the thiol compounds made were obtained as enantiopure samples and were characterized employing NMR and mass spectrometry.
Madhu, Chilakapati,Hemantha, H. P.,Vishwanatha, T. M.,Sureshbabu, V. V.
p. 228 - 235,8
(2020/09/02)
Modified tripeptides
Modified oxytocin-vasopressin di- or tri-peptides wherein an amide group is replaced by a group selected from STR1 --CH2 NH--, --CH2 O--, --CH2 S--, --CH2 SO--, --CH2 SO2 --, --CH2/su
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(2008/06/13)
Modified Di- and Tripeptides of the C-Terminal Portion of Oxytocin and Vasopressin as Possible Cognition Activation Agents
A number of peptides and modified peptides were synthesized and studied for their ability to reverse electroconvulsive shock-induced amnesia in rodents.A few of these peptides were selected for secondary evaluation in tests of short-term memory in rats and aged rhesus monkeys.A number of the peptides and modified peptides were active in the amnesia reversal test.In selected secondary tests, however, the chosen compounds failed to show significant activity in enhancing memory.New methods for preparing methyleneamino and methyleneoxy isosters of peptides are reportrd.Other modified peptides also included methylenethio, methylenesulfonyl, and ethylene isosteres in place of the normal peptide amide bond.
Nicolaides, E. D.,Tinney, F. J.,Kaltenbronn, J. S.,Repine, J. T.,DeJohn, D. A.,et al.
p. 959 - 971
(2007/10/02)
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