cas 1043868-97-8, N-(2-Methoxybenzyl)-2-(2,5-dimethoxy-4-iodophenyl)ethanamine HCl

Articles about 1043868-97-8Total 2 be found

N -Benzyl-5-methoxytryptamines as Potent Serotonin 5-HT2 Receptor Family Agonists and Comparison with a Series of Phenethylamine Analogues
A series of N-benzylated-5-methoxytryptamine analogues was prepared and investigated, with special emphasis on substituents in the meta position of the benzyl group. A parallel series of several N-benzylated analogues of 2,5-dimethoxy-4-iodophenethylamine
Nichols, David E.,Sassano, M. Flori,Halberstadt, Adam L.,Klein, Landon M.,Brandt, Simon D.,Elliott, Simon P.,Fiedler, Wolfgang J.
p. 1165 - 1175
(2015)
Read Online

High specific activity tritium-labeled N-(2-methoxybenzyl)-2,5-dimethoxy-4-iodophenethylamine (INBMeO): A high-affinity 5-HT2A receptor-selective agonist radioligand
The title compound ([3H]INBMeO) was prepared by an O,O-dimethylation reaction of a t-BOC protected diphenolic precursor using no carrier added tritiated iodomethane in DMF with K2CO3. Removal of the t-BOC protecting group and purification by HPLC afforded an overall yield of 43%, with a radiochemical purity of 99% and specific activity of 164 Ci/mmol. The new radioligand was suitable for labeling human 5-HT2A receptors in two heterologous cell lines and had about 20-fold higher affinity than [3H]ketanserin.
Nichols, David E.,Frescas, Stewart P.,Chemel, Benjamin R.,Rehder, Kenneth S.,Zhong, Desong,Lewin, Anita H.
p. 6116 - 6123
(2008/12/21)

Chemical Properties

This product is a nationally controlled contraband, and the Lookchem platform doesn't provide relevant sales information.