- Quinolines derivatives as novel sunscreening agents
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Currently, the research and development of sunscreens play an important role on the synthesis of actives that are stable in various kinds of formulations - in addition to their efficiency and broad spectrum of protection against ultraviolet radiation. Our
- Polonini, Hudson C.,Dias, Rafael M.P.,Souza, Isabela O.,Gon?alves, Karla Mara,Gomes, Tiago B.B.,Raposo, Nádia R.B.,Da Silva, Adilson David
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p. 4506 - 4510
(2013/08/23)
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- Process for the preparation of 4-amino-chloroquinolines
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4-Amino-chloroquinolines of the formula: STR1 in which R1 represents a hydrogen atom or an alkyl radical (1 to 5 carbon atoms), and R2 represents an alkyl radical (1 to 5 carbon atoms) optionally substituted by a dialkylamino group, or a phenyl radical optionally substituted by one or more carboxy and hydroxy radicals and alkyl radicals (1 to 4 carbon atoms) optionally substituted by a dialkylamino group, are prepared by the condensation of an amine of the formula: STR2 with a chloro-1,2,3,4-tetrahydroquinolin-4-one of the formula: STR3 with aromatization of the tetrahydroquinoline, the reaction being carried out in the presence of a ruthenium based catalyst on a support. The 4-amino-chloroquinoline products are useful as pharmaceuticals.
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