104408-23-3

Basic information

• Product Name: (3,5-DICHLORO-PYRIDIN-2-YL)-HYDRAZINE
• Synonyms: 3,5-dichloro-2-hydrazinylpyridine;Pyridine,3,5-dichloro-2-hydrazinyl-
• CAS NO: 104408-23-3
• Molecular Formula: C₅H₅Cl₂N₃
• Molecular Weight: 178.02
• Mol File: 104408-23-3.mol

Chemical Properties

• Appearance: /
• Storage Temp.: Inert atmosphere,Store in freezer, under -20°C
• CAS DataBase Reference: (3,5-DICHLORO-PYRIDIN-2-YL)-HYDRAZINE(CAS DataBase Reference)
• NIST Chemistry Reference: (3,5-DICHLORO-PYRIDIN-2-YL)-HYDRAZINE(104408-23-3)
• EPA Substance Registry System: (3,5-DICHLORO-PYRIDIN-2-YL)-HYDRAZINE(104408-23-3)

Safety Data

• Hazardous Substances Data: 104408-23-3(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
(3,5-DICHLORO-PYRIDIN-2-YL)-HYDRAZINE is used as a reactant for the synthesis of (1S,3R)-N-[1-(3-chloropyridin-2-yl)-5-(5-fluoro-6-methylpyridin-3-yl)-4-methyl-1H-pyrazol-3-yl]methyl-3-fluorocyclopentanamine. This synthesized compound is a potential antagonist of the opioid receptor-like 1 (ORL1), which may have therapeutic applications in the treatment of pain and addiction.
The compound (3,5-DICHLORO-PYRIDIN-2-YL)-HYDRAZINE plays a crucial role in the development of novel pharmaceuticals targeting the ORL1 receptor. By acting as an antagonist, the synthesized compound may help in modulating the pain response and potentially reduce the risk of addiction associated with traditional opioid medications. This makes it a valuable compound in the ongoing search for more effective and safer pain management options.

Upstream product

• 16063-70-0 2,3,5-trichloropyridine 

Downstream Products

• 334685-40-4 2-[(3,5-dichloro-pyridin-2-yl)-hydrazonomethyl]-phenol 
• 334685-56-2 4-{1-[(3,5-dichloro-pyridin-2-yl)-hydrazono]-ethyl}-3-methyl-phenol 
• 334685-44-8 N-(3,5-Dichloro-pyridin-2-yl)-N'-[1-(4-nitro-phenyl)-meth-(E)-ylidene]-hydrazine 
• 334685-41-5 4-[(3,5-dichloro-pyridin-2-yl)-hydrazonomethyl]-phenol 
• 334685-42-6 N-(3,5-Dichloro-pyridin-2-yl)-N'-[1-(4-methoxy-phenyl)-meth-(E)-ylidene]-hydrazine 
• 334685-43-7 {4-[(3,5-dichloro-pyridin-2-yl)-hydrazonomethyl]-phenyl}-dimethyl-amine 
• 334685-50-6 2,6-di-tert-butyl-4-[(3,5-dichloro-pyridin-2-yl)-hydrazonomethyl]-phenol 
• 354531-27-4 N-(3,5-Dichloro-pyridin-2-yl)-N'-[1-phenyl-meth-(E)-ylidene]-hydrazine 

Relevant articles and documents

Synthesis and Insecticidal Evaluation of Novel Anthranilic Diamides Derivatives Containing 4-Chlorine Substituted N-Pyridylpyrazole

To search for potent insecticides targeting at ryanodine receptors (RyRs), a series of novel anthranilic diamides analogs containing 4-chlorine N-pyridylpyrazole were designed and synthesized. Their insecticidal activities were evaluated and the preliminary structure-activity relationships (SARs) were discussed. The insecticidal results showed that some of the compounds (8a—8h, 8m, 8n) exhibited good larvicidal activities against oriental armyworm at 2.5 mg·L–1, and compound 8m possessed 60% insecticidal activity at 0.5 mg·L–1. For diamondback moth, 8m exhibited better activity than Chlorantraniliprole at a hundred fold preference. The calcium imaging technique experiment results suggested that compound 8m could increase the intracellular [Ca2+]i. With the neurons preincubated experiment, the results confirmed that the target of this series of compounds could be RyRs in the central larvae neurons of oriental armyworm. The results indicated that compound 8m could respond as a potential modulator of the insect ryanodine receptor.

Synthesis, bioactivity, action mode and 3D-QSAR of novel anthranilic diamide derivatives

To study the pesticide effect, action mode, structure-activity relationships (SARs) of anthranilic diamide insecticide and screen highly active pesticides, novel anthranilic diamide derivatives were synthesized. Bioassays indicated that all of the title compounds displayed 100% mortality against diamondback moth and oriental armyworm at 100 mg/L, among which 12v and 12w showed 100% insecticidal acitvity at 5 mg/L. Surprisingly compound 12w exhibited better insecticidal acitvity than commercialized chlorantraniliprole against Pyrausta nubilalis (0.1 mg/L) and Cnaphalocrocis Medinalis (2 mg/L). 3D-QSAR and SARs statistical analysis revealed that title compounds with R2 fixed as methoxy had the highest probability possessing high activity. The calcium fluorescence measurements on neurons revealed that E series compounds containing pyrazinyl may have a molecular target different from caffeine on ryanodine receptors rather than the voltage-gated calcium channel present on cytomembran.

AMIDOPYRIDINE DERIVATIVE, AND USE THEREOF

The present invention relates to novel amidopyridine derivatives. More specifically, the present invention provides a medicinal agent which is useful as a prophylactic or therapeutic agent for diseases based on the production of cytokines from T cells, comprising as the active ingredient an amidopyridine derivative or a pharmacologically acceptable salt thereof. Provided are an amidopyridine derivative of the following general formula (I): wherein each symbol has the same meaning as defined in the description, or a pharmacologically acceptable salt thereof.

1-Substituted Pyridyl-Pyrazolyl Amide Compounds and Uses Thereof

The present invention discoses a kind of 1-substituted pyridyl-pyrazolyl amide compounds and uses thereof. The compounds have structures as represented by the general formula I, wherein the definitions of each substituent showed in the specification. The compounds of formula I are novel and have excellent insecticidal and fungicidal activities and can be used for controlling insect pest and diseases.

HETEROCYCLIC MODULATORS OF GPR119 FOR TREATMENT OF DISEASE

The present invention relates to compounds and methods which may be useful as inhibitors of GPR119 for the treatment or prevention of metabolic, cardiovascular, and metabolic diseases.

Synthesis of 1,3-diazepines and ring contraction to cyanopyrroles

Several tetrazolo[1,5-a]pyridines/2-azidopyridines undergo photochemical nitrogen elimination and ring expansion to 1,3-diazacyclohepta-1,2,4, 6-tetraenes (7,10,13,16,19,22) as well as ring cleavage to cyanovinylketenimines (8,17,20b) in low temperature Ar matrices. 6,8-Dichlorotetrazolo[1,5-a]pyridine/2-azido-3,5-dichloropridine 6 undergoes ready exchange of the chlorine in position 8 (3) with ROH/RONa. 8-Chloro-6-trifluoromethylletrazolo[1,5-a]pyridine 15 undergoes solvolysis of the CF3 group to afford 8-chloro-6-methoxycarbonyltetrazolo[1,5-a]pyridine 18. Several tetrazolopyridines/2-azidopyridines afford 1H- or 5H-1,3-diazepines in good yields on photolysis in the presence of alcohols or amines (11,14,23,25). 5-Chlorotetrazolo[1,5-a]pyridines/2-azido-6-chloropyridines 21 and 38 undergo a rearrangement to 1H-and 3H-3-cyanopyrroles 27 and 45, respectively. The mechanism of this rearrangement was investigated by 15N-labelling and takes place via transient 1,3-diazepines. The structures of 6,8-dichloro-tetrazolo[1,5-a]pyridine 6T, 6-chloro-8-ethoxytetrazoIo[1,5-a]pyridine 9Tb, dipyrrolylmethane 28, and 2-isopropoxy-4-dimethylamino-5H-1,3-diazepine 25b were determined by X-ray crystallography. In the latter case, this represents the first reported X-ray crystal structure of a 5H-1,3-diazepine.

Synthesis of N-substituted 3-aminothiazolidin-4-ones containing hetaryl fragments

Condensation of the N-(3,5-dichloropyridyl-2)- and N- (benzothiazolyl-2-thioacetyl)hydrazones of carbonyl compounds with thioglycolic acid gave the 3-(3,5-dichloropyridyl-2)amino- and 3-[N-(benzothiazolyl-2-thioacetyl)amino]-2-R1-2-R2/sup

Halogen-containing pyridines. 7. Synthesis and some conversions of (3,5-dichloro-2-pyridyl)hydrazine

(3,5-Dichloro-2-pyridyl)hydrazine was synthesized by the interaction of 2,3,5-trichloropyridine with hydrazine hydrate. Reaction of the former with carbonyl compounds gave N-(3,5-dichloro-2-pyridyl)hydrazones, and with acid anhydrides N′-acyl derivatives were formed. Azodyestuffs containing 3,5-dichloropyridyl fragments were obtained from some of the hydrazones synthesized.

Synthesis of 1H- and 5H-1,3-diazepines from azido- and tetrazolo-pyridines

Stable 1H-1,3-diazepines 7-9, 10, 13, 14, 17 and 19 are obtained, often in high yields, by photolysis of trifluoromethyl-substituted azido- or tetrazolo-pyridines in the presence of alcohols or amines; in some cases, 5H-1,3-diazepines are also formed (11, 21 and 23).