- Synthesis of enantiomeric aminophosphonic acids and peptides
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Synthesis of enantiomeric amino phosphonic acids APA is described by using chiral auxiliary reagent or enzymatic resolution of racemic mixtures of APA phenacyl derivatives.Peptides with APA residue were obtained by application of trimethylsilyl derivatives or condensation in the presence of enzyme-papain. - Keywords: aminophosphonic acids, enantiomers, peptides, enzymes
- Kukhar, Valery,Solodenko, Vladimir,Soloshonok, Vadim,Kasheva, Tamara
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p. 529 - 532
(2007/10/03)
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- PREPARATION OF BENZYL N-BENZYLOXYCARBONYLAMINOPHOSPHONATES AND -AMINOPHOSPHONITES - THE SCOPE AND LIMITATIONS OF O-BENZYL-N,N'-DICYCLOHEXYLOISOUREA METHOD
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Protection of the amino group of aminophosphonic and aminophosphonous acids with benzyl chloroformate followed by esterification of the N-protected derivatives with O-benzyl-N,N'-dicyclohexyloisoureas is described.The esterification of aminobenzylphosphonic and aminobenzylphosphonous acids was studied in some details in order to discuss the scope and limitation of this procedure.The differences in the reactions of aminoalkylphosphonic and aminoalkylphosphonous acids are pointed out.Key words: Aminobenzylphosphonic and -phosphonous acid, N-benzyloxycarbonyl derivatives, esterification, O-benzyl-N,N'-dicyclohexyloisourea, benzyl N-benzyloxycarbonylaminobenzylphosphonate and phosphonite.
- Mucha, Artur,Kafarski, Pawel,Plenat, Francoise,Cristau, Henri-Jean
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p. 187 - 194
(2007/10/02)
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