- Organic phosphorus compounds. Part 3. Synthesis of 5-fluorosubstituted benzothiazolylbenzylphosphonates
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The regio specific synthesis of 5-fluorobenzothiazoles 14 has been accomplished by using difluorothiobenzanilides 13 as a key intermediate. Through this method, 5-fluorosubstituted fostedil 3 and its derivatives were synthesized and evaluated coronary vas
- Yoshino,Hori,Hori,Morita,Tsukamoto
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p. 1039 - 1043
(2007/10/02)
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- Novel ethyl benzylphosphinate derivatives, process for production thereof, and their use as calcium antagonist
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An ethyl benzylphosphinate derivative represented by the general formula (I) STR1 wherein Y represents a hydrogen or fluorine atom, X represents a methylene group or an oxygen atom, and n is 2, 3 or 4. The said compounds can be produced by reacting a compound represented by the following formula (II) STR2 wherein Y is as defined above, with a compound represented by the following formula (III) STR3 wherein X and n are as defined, and M is an alkali metal atom, in an inert medium. These compounds are useful as a calcium antagonist.
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